. 2014 Sep 3;9(9):e106101. doi: 10.1371/journal.pone.0106101

Table 3. Chemical specific model parameters.

Parameters	Adult Humans		Children	Adult Monkeys		Juvenile Monkeys		Method of calibration
	IV	Oral	Oral	IV	Oral	IV	Oral
Methylphenidate (MPH)
Hepatic hydrolysis
Kmliverd (µg/L)	27,600	27,600	27,600	27,600	27,600	27,600	27,600	[16]
Kmliverl (µg/L)	10,172	10,172	10,172	10,172	10,172	10,172	10,172	[16]
VmaxliverdC (µg/h/kg^0.75)	38,000	38,000	38,000^a	38,000^a	38,000^a	350,000	350,000	[16] ^H and visual fit
VmaxliverlC (µg/h/kg^0.75)	90,000	90,000	90,000^a	90,000^a	90,000^a	700,000	700,000	[16] ^H and visual fit
Hepatic oxidation
KmetdC and KmetlC (L/h/kg^0.75)	0.7	0.7	0.7^a	0.7^a	0.7^a	70	70	[18] ^H and visual fit
Gastric emptying
GEdC and GElC (1/h/kg^−0.25)	/	3.5	3.5^a	/	2.34	/	2.34	[78] ^H [63] ^M
Oral uptake, from small intestine to liver
K3dC and K3lC (1/h/kg^−0.25)	/	1.293	1.293^a	/	1.293^a	/	1.293^a	Optimization^H
Gut metabolism
K5dC (1/h/kg^0.75)	/	0.042	0.042^a	/	1.05	/	/	Optimization^H and visual fit
K5lC (1/h/kg^0.75)	/	1.426	0.1	/	35.65	/	/	Optimization^H and visual fit
F	/	0.8	0.8^a	/	0.8^a	/	/	[18] ^H
Ritalinic acid (RA)
Volume of distribution (VbodyC, L/kg)	0.600	0.600	0.572	0.693	0.693	0.693	0.693	Set to total body water volume: [80] ^H ^,M [84], [85] ^C
Urinary excretion
Ku_RAdC (L/h/kg^0.75)	0.305	0.305	0.305^a	0.305^a	0.305^a	0.305^a	0.305^a	Optimization^H
Ku_RAlC (L/h/kg^0.75)	0.168	0.168	0.168^a	0.168^a	0.168^a	0.168^a	0.168^a	Optimization^H

adult humans;^Cchildren; ^Mmonkeys; ^aset to adult human values.