Table 3.
PMPMEase expression in various pancreatic tissue. Mean ± SEM.
| Characteristic | PMPMEase Staining Intensity, N (%) | Normal | NAT | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 1–100 Trace |
101–200 Weak |
201–300 Intermediate |
301–400 Strong |
401–500 Very strong |
Total cases |
Mean Score | p-value t-test |
p-value t-test |
|
| Histology | |||||||||
| Normal pancreatic tissue | 7 (70.0) | 3 (30.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 10 | 115.0 ± 7.6 | ||
| Normal adjacent tissue | 6 (30.0) | 14 (70.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 20 | 145.0 ± 8.6 | ||
| Adenosquamous carcinoma | 0 (0.0) | 2 (66.7) | 1 (33.3) | 0 (0.0) | 0 (0.0) | 3 | 183.3 ± 46.4 | 0.0268 | ns |
| Chronic inflammation | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (50.0) | 1 (50.0) | 2 | 412.5 ± 12.5 | <0.0001 | <0.0001 |
| Chronic pancreatitis | 1 (50.0) | 1 (50.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 | 112.5 ± 12.5 | ns | ns |
| Duct adenocarcinoma | 0 (0.0) | 3 (7.1) | 3 (7.1) | 17 (40.5) | 19 (45.2) | 42 | 393.6 ± 14.4 | <0.0001 | <0.0001 |
| Hyperplasia | 0 (0.0) | 1 (50.0) | 1 (50.0) | 0 (0.0) | 0 (0.0) | 2 | 212.5 ± 62.5 | 0.0059 | 0.0446 |
| Islet cell carcinoma | 0 (0.0) | 0 (0.0) | 1 (100.0) | 0 (0.0) | 0 (0.0) | 1 | 250.0 ± 0.0 | - | - |
| Islet cell tumor | 4 (40.0) | 1 (10.0) | 3 (30.0) | 1 (10.0) | 1 (10.0) | 10 | 225.0 ± 48.3 | 0.0372 | 0.0333 |
| Mild chronic inflammation | 2 (33.3) | 1 (16.7) | 2 (33.3) | 1 (16.7) | 0 (0.0) | 6 | 204.2 ± 48.5 | 0.0342 | ns |
| Type | |||||||||
| Benign | 4 (40.0) | 1 (10.0) | 3 (30.0) | 1 (10.0) | 1 (10.0) | 10 | 225.0 ± 48.3 | 0.0372 | 0.0333 |
| Hyperplasia | 0 (0.0) | 1 (50.0) | 1 (50.0) | 0 (0.0) | 0 (0.0) | 2 | 212.5 ± 62.5 | 0.0059 | 0.0446 |
| Inflammation | 3 (30.0) | 2 (20.0) | 2 (20.0) | 2 (20.0) | 1 (10.0) | 10 | 227.5 ± 43.4 | 0.0199 | 0.0171 |
| Malignant | 0 (0.0) | 5 (10.9) | 5 (10.9) | 18 (39.1) | 18 (39.1) | 46 | 374.5 ± 55.2 | <0.0001 | <0.0001 |
| Grade | |||||||||
| 1 | 0 (0.0) | 2 (25.0) | 1 (12.5) | 3 (37.5) | 2 (25.0) | 8 | 328.1 ± 39.9 | <0.0001 | <0.0001 |
| 2 | 0 (0.0) | 0 (0.0) | 1 (6.7) | 6 (40.0) | 8 (53.3) | 15 | 411.7 ± 19.6 | <0.0001 | <0.0001 |
| 3 | 0 (0.0) | 0 (0.0) | 1 (7.1) | 7 (50.0) | 6 (42.9) | 14 | 408.9 ± 22.2 | <0.0001 | <0.0001 |
| Tumor status | |||||||||
| 1 | 0 (0.0) | 0 (0.0) | 0 * (0.0) | 0 (0.0) | 2 (100.0) | 2 | 425.0 ± 25.0 | <0.0001 | <0.0001 |
| 2 | 0 (0.0) | 2 (7.4) | 3 (11.1) | 11 (40.7) | 11 (40.7) | 27 | 384.3 ± 19.2 | <0.0001 | <0.0001 |
| 3 | 0 (0.0) | 3 (20.0) | 1 (6.7) | 5 (33.3) | 6 (40.0) | 15 | 356.7 ± 31.9 | <0.0001 | <0.0001 |
| 4 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (50.0) | 1 (50.0) | 2 | 450.0 ± 50.0 | <0.0001 | <0.0001 |
| Nodal status | |||||||||
| 0 | 0 (0.0) | 2 (5.4) | 3 (8.1) | 16 (43.2) | 16 (43.2) | 37 | 390.5 ± 15.6 | <0.0001 | <0.0001 |
| 1 | 0 (0.0) | 3 (37.5) | 1 (12.5) | 2 (25.0) | 2 (25.0) | 8 | 325.0 ± 51.1 | 0.0003 | <0.0001 |
| Metastasis | |||||||||
| 0 | 0 (0.0) | 5 (11.6) | 4 (9.3) | 18 (41.9) | 16 (37.2) | 43 | 374.4 ± 16.3 | <0.0001 | <0.0001 |
| 1 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 3 (100.0) | 3 | 458.3 ± 22.0 | <0.0001 | <0.0001 |