Table 1.
Bioinformatics of ethanol-responsive genes in the prefrontal cortex of C57BL/6J mice.
| Change | Gene symbol (gene name) | Proposed function | P value |
|---|---|---|---|
| Ras/MAPK signaling pathway | |||
| ↑ | Elk1 (ELK1, member of ETS oncogene family) | Up-regulation of IEG | 1.3E-06 |
| ↑ | Ulk1 (Unc-51-like kinase 1) | Axon formation | 1.1E-04 |
| ↑ | Rhob (ras homolog gene family, member B) | Endosome transport | 1.3E-04 |
| ↑ | Hrasls (HRAS-like suppressor) | Regulation of cell growth | 2.1E-04 |
| ↑ | Erk1 (extracellular signal related protein 1) | Synaptic plasticity | 2.3E-04 |
| ↓ | Egr1 (early growth response 1) | Inhibition of gene transcription | 5.5E-03 |
| ↑ | Nras (neuroblastoma ras oncogene) | Regulation of cell cycle | 6.3E-03 |
| ↓ | Prkca (protein kinase C, alpha) | Inhibition of ERK1 | 6.3E-03 |
| ↓ | Bdnf (brain derived neurotrophic factor) | Neuron development | 6.3E-03 |
| ↑ | Rab8a (RAB8A, member of RAS oncogene family) | Protein transport | 6.4E-03 |
| ↑ | Oprl1 (Opioid receptor-like 1) | Ras/MAPK activator | 7.0E-03 |
| Notch signaling pathway | |||
| ↑ | Sel1h (suppressor of lin-12 homolog 1) | Transcription repressor | 5.5E-03 |
| ↓ | Aph1a (anterior pharynx defective 1a homolog) | Gamma-secratase complex | 5.5E-03 |
| ↑ | Adam 10 (a disitegrin and metallopeptidase 10) | Proteolytic cleavage | 5.5E-03 |
| ↑ | Adam 19 (a disitegrin and metallopeptidase 19) | Proteolytic cleavage | 6.3E-03 |
| ↓ | Dtx2 (deltex 2 homolog) | Transcriptional regulator | 7.7E-03 |
| Ubiquitylation | |||
| ↑ | Ube2l3 (ubiquitin-conjugating enzyme E2L 3) | Protein modification | 5.5E-03 |
| ↑ | Ufd1l (ubiquitin fusion degradation 1-like) | Protein catabolic process | 5.5E-03 |
| ↑ | Anapc7 (anaphase promoting complex 7) | Protein catabolic process | 6.1E-03 |
| ↑ | Ufc1 (ubiquitin-fold conjugating enzyme 1) | Protein catabolic process | 7.0E-03 |
| ↑ | Ube2i (ubiquitin-conjugating enzyme E2I) | Protein modification | 7.0E-03 |
| ↑ | Nedd4 (neuronal developmental down-regulated 4) | Protein modification | 7.4E-03 |
| ↑ | Ube2g2 (ubiquitin-conjugating enzyme E2G 2) | Protein modification | 7.4E-03 |
| ↑ | Rbx1 (ring-box 1) | DNA repair | 7.5E-03 |
P values indicate the level of significance in gene expression as determined by significance analysis of microarrays and the proposed function as determined by GeneMesh. Arrows indicate the direction (up- or down-regulation) of changes in gene expression.