Table 2.
Bioinformatics of withdrawal-responsive genes in the hippocampus of C57BL/6J mice.
| Change | Gene symbol (gene name) | Proposed function | P values |
|---|---|---|---|
| RNA processing | |||
| ↑ | Jak1 (Janus kinase 1) | RNA binding | 1.2E-05 |
| ↑ | Ptpn4 (protein tyrosine phosphatase, nonreceptor 4) | Hydrolase activity | 6.3E-05 |
| ↑ | Eif4g1 (eukaryotic translation factor 4, gamma 1) | Translation initiation factor | 1.8E-04 |
| ↑ | Papola (poly A polymerase alpha) | Transferase activity | 2.1E-04 |
| ↑ | Gm672 (gene model 672) | RNA binding | 2.3E-04 |
| ↑ | Zfml (zinc finger, matrin-like) | Nuclear mRNA splicing | 3.3E-04 |
| ↓ | Srpk2 (serine/arginine protein kinase 2) | Nuclear mRNA splicing | 6.1E-04 |
| ↑ | Cstf2 (cleavage stimulation factor, 3′ pre-RNA 2) | mRNA polyadenylation | 7.0E-04 |
| ↑ | Ssb (Sjogren syndrome antigen B) | RNA-nucleus export | 7.6E-04 |
| ↑ | Stau2 (Staufen homolog 2) | RNA binding | 7.6E-04 |
| ↑ | Rbm5 (RNA binding motif protein 5) | mRNA binding | 1.0E-03 |
| ↑ | Ddx10 (DEAD box polypeptide 10) | Helicase activity | 1.2E-03 |
| ↑ | Csde1 (cold shock domain containing E1) | RNA binding | 1.2E-03 |
| ↓ | Nola3 (nuclear protein family A, member 3) | rRNA processing | 2.8E-03 |
| Actin dynamics | |||
| ↑ | Gmfb (glia maturation factor, beta) | Actin binding | 1.8E-04 |
| ↑ | Sntb2 (syntrophin, basic 2) | Actin binding | 3.5E-04 |
| ↓ | Med28 (mediator of RNA polymerase II, subunit 28) | Actin binding | 4.7E-04 |
| ↑ | Braf (Braf transforming gene) | Actin nucleation | 4.9E-04 |
| ↑ | Kif5b (kinesin family member 5B) | Axonal transport | 8.1E-04 |
| ↑ | Enah (enabled homolog) | Actin polymerization | 1.0E-03 |
| ↑ | Spnb2 (spectrin beta 2) | Actin filament capping | 1.0E-03 |
P values indicate the level of significance in gene expression as determined by significance of analysis microarrays and the proposed function as determined by GeneMesh. Arrows indicate the direction (up- or down-regulation) of changes in gene expression.