Table 2. Down-regulated miRNAs in aged muscle.
MiRNAs with >1.5-fold change in expression between young (6-month-old) and aged (24-month-old) muscles are listed from top to bottom according to fold changes and values of differences. MiRNAs in bold indicate TaqMan qRT-PCR validation.
| miRNA | Fold Change | P-value |
|---|---|---|
| mmu-miR-337-5p | −5.2 | 0.0149 |
| mmu-miR-3544-3p | −5.1 | 0.0147 |
| mmu-miR-540-5p | −4.9 | 0.0200 |
| mmu-miR-337-3pa | −3.0 | 0.0324 |
| mmu-miR-3544-5pa | −3.0 | 0.0308 |
| mmu-miR-434-3p | −2.1 | 0.0001 |
| mmu-miR-3071-5p | −2.0 | 0.0004 |
| mmu-miR-136-3pa | −2.0 | 0.0004 |
| mmu-miR-3071-3pa | −1.6 | 0.0000 |
| mmu-miR-136-5p | −1.6 | 0.0000 |
| mmu-miR-143-5p | −1.2 | 0.0004 |
| mmu-miR-190a-5p | −1.0 | 0.0139 |
| mmu-miR-872-3p | −0.9 | 0.0152 |
| mmu-miR-193a-3p | −0.9 | 0.0164 |
| mmu-miR-144-3p | −0.8 | 0.0298 |
| mmu-miR-127-3p | −0.7 | 0.0002 |
| mmu-miR-434-5pa | −0.6 | 0.0082 |
| mmu-miR-148a-3p | −0.6 | 0.0130 |
| mmu-miR-411-5p | −0.6 | 0.0091 |
a
miRNA* (passenger) strand processed from opposite arm of the mature miRNA.