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. 2014 Jul 19;6(7):564–574. doi: 10.18632/aging.100679

Figure 2. Changes in DNA methylation pattern in senescent cells.

Figure 2

(A) Number of CpG sites affected by differential methylation comparing PD 47 and PD 54 to PD 38 cultures. (B) Number of CpG sites in the given comparisons affected by hypo- (dark grey) or hypermethylation (light grey). (C) Distribution of CpG methylation changes across the chromosomes. Top: changes between PD 47 and PD 38; Bottom: changes between PD 54 and PD 38. Black/grey lines indicate gene densities, green lines represent CpG sites hypomethylated in the older cultures and red lines indicate CpG sites hypermethylated in older cultures.