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. 2014 Sep 3;9(9):e106335. doi: 10.1371/journal.pone.0106335

Figure 1. Increased plasma levels of intestinal permeability markers during EAE progression.

Figure 1

Sodium fluorescein, Na-F (MW 376 Da) (A), FITC-BSA (MW 66 KDa) (B) in unimmunized animals (control), EAE mice at day 7 (EAE7) and day 14 (EAE14) following immunization, and mice at day 14 after immunization with CFA without MOG followed by administration of pertussis toxin (CFA). Marker levels were measured in plasma samples taken at 1 h after gavage with a saline solution containing the indicated marker for Na-F and 2 h for FITC-BSA. The results are expressed as mean ±SD, (n = 7–10). * represents a p-value≤0.05, ** a p-value≤0.01.