Table 4. Crude associations of the CHA₂DS₂-VASc score and combinations of the score plus C-reactive protein, fibrinogen or TnI, or the CHA₂DS₂-VASc score plus all three biomarkers with unfavourable 30-day functional outcome of ischemic stroke and pairwise comparisons of the scores.

	Score	OR	95%CI	P	c-statistic	95%CI	P	z-statistic	P
1	CHA2DS2-VASc	7.9	4.6–13.4	<0.001	0.932	0.892–0.960	<0.001	2.268 (2 vs. 1)	0.0233
2	CHA2DS2-VASc-CRP	5.9	3.8–9.3	<0.001	0.948	0.911–0.972	<0.001	2.020 (3 vs. 1)	0.0434
3	CHA2DS2-VASc-F	6.0	3.8–9.5	<0.001	0.946	0.909–0.971	<0.001	3.274 (4 vs. 1)	0.0011
4	CHA2DS2-VASc-T	10.0	5.3–18.9	<0.001	0.955	0.921–0.978	<0.001	1.947 (5 vs. 1)	0.0515
5	CHA2DS2-VASc-CRFT	3.6	2.6–4.8	<0.001	0.953	0.917–0.976	<0.001	1.514 (3 vs. 2)	0.1299
								1.242 (4 vs. 2)	0.2144
								0.995 (5 vs. 2)	0.3195
								1.433 (4 vs. 3)	0.1517
								1.267 (5 vs. 3)	0.2053
								0.427 (5 vs. 4)	0.6692

CHA₂DS₂-VASc, congestive heart failure or left ventricular ejection fraction ≤40%, hypertension, age ≥75 years, diabetes mellitus, prior stroke or TIA, vascular disease (including myocardial infarction and peripheral artery disease), age >65 years, female gender (1 point each, age ≥75 years and prior stroke/TIA 2 points each); CHA₂DS₂-VASc-CRP, 1 additional point if C-reactive protein was >4 mg/L; CHA₂DS₂-VASc-F, 1 additional point if fibrinogen was >3.7 g/L; CHA₂DS₂-VASc-T, 1 additional point if TnI was >0.09µg/L; CHA₂DS₂-VASc-CRPFT, 1 additional point for each of three biomarkers if above the correspondent cut-off level.