Table 3.
Prevalence of Autoantibodies and Antinuclear Antibodies Patterns Among Morphea Subtypes and Age-, Sex-, and Race-Matched Controlsa
| Autoantibodies | Patients, No. (%)
|
P Value (vs Controls)
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Morphea Subtype
|
Total Group of Patients With Morphea (n = 187) | Controlsb | Total Group of Patients With Morphea | Morphea Subtype
|
|||||
| Generalized (n = 73) | Linear (n = 85) | Plaque (n = 18) | Generalized | Linear | Plaque | ||||
| Positive ANA | 26 (36) | 28 (33) | 6 (33) | 63 (34) | 69 (11) | <.001 | NS | NS | NS |
|
| |||||||||
| Speckled | 21 (29) | 24 (28) | 4 (24) | 52 (28) | 56 (9) | <.001 | NS | NS | NS |
|
| |||||||||
| Positive | |||||||||
|
| |||||||||
| Anti-ssDNA | 3 (4) | 11 (13)c | 1 (6) | 15 (8) | 10 (7) | NS | NS | NS | NS |
|
| |||||||||
| AHA | 5 (7) | 15 (18)d | 1 (6) | 22 (12) | 3 (2) | <.001 | NS | .02e | NS |
Abbreviations: AHA, antihistone antibody; ANA, antinuclear antibody; anti-ssDNA, anti–single-stranded DNA; NS, nonsignificant.
Unless indicated, there were no other significant associations seen between autoantibodies and morphea subtypes.
For ANA, n = 651; for anti-ssDNA and antihistone, n = 149.
P = .06 for an association between anti-ssDNA and linear subtype (vs nonlinear subtypes).
P = .04 for an association between AHA and linear subtype (vs nonlinear subtypes).
Bonferroni correction for multiple comparisons would yield an α level of .0167. Because .0170 is greater than .0167, this value becomes nonsignificant with correction.