Skip to main content
. 2014 Sep 3;9(9):e106764. doi: 10.1371/journal.pone.0106764

Figure 4. FXR KO affects the alpha and beta diversity of the cecal microbiome.

Figure 4

A) Sham FXR KO mice showed significant decreases in OTU richness as measured by Chao1. B) Decreased alpha diversity was also observed using the Shannon diversity index when compared to sham WT and H. hepaticus infected FXR KO mice. C) Unweighted UniFrac-based PCoA plot of cecal microbial communities from WT and FXR KO mice with and without H. hepaticus infection reveals clustering based on mouse genotype and H. hepaticus status (P = 0.001 for both, PERMANOVA). D) Weighted Unifrac-based PCoA plot reveals clustering by mouse genotype (P = 0.005, PERMANOVA), but not by H. hepaticus status. *, P<0.05 against both sham WT and H. hepaticus FXR KO mice.