Table 4. Results of haplotype analysis in anti-CCP negative RA patients in association with cerebrovascular events.

Variable		HR (95% CI)	p
	Age at RA diagnosis (by each year)	1.09 (1.05–1.13)	<0.001
	Hypertension	1.13 (0.51–2.48)	0.769
	Diabetes mellitus	3.71 (1.78–7.70)	<0.001
	Obesity	1.28 (0.58–2.83)	0.547
	Dyslipidemia	0.80 (0.39–1.66)	0.556
	Smoking	1.13 (0.68–1.88)	0.632
Haplotypes (rs3134063, rs2073618, rs3134069)		HR (95% CI) *	p *
	TCA	1 (reference)	-
	TGA	1.38 (0.56–3.42)	0.487
	CCA	1.16 (0.49–2.76)	0.740
	CGA	0.17 (0.04–0.78)	0.022

CCP: cyclic citrullinated protein/peptide antibodies; CI: confidence interval; CV: cardiovascular; HR: hazard ratios; RA: rheumatoid arthritis.

*Adjusted for sex, age at RA diagnosis and traditional CV risk factors (hypertension, diabetes mellitus, dyslipidemia, obesity, and smoking habit).