Vaccination, challenge and sampling schedule. Cynomolgus macaques were divided into two groups (BCG- and sham-vaccinated control) of four per group as follows: Animals Group 1: IF16 & IF21 (BCG, TB + 5 weeks); IF23 & IF18 (saline, TB + 5 weeks). Animals Group 2: IF20 & IF17 (BCG, TB + 10 weeks); IF19 & IF22 (saline, TB + 10 weeks). Groups 1 and 2 were sacrificed after 5 and 10 weeks post-challenge with Mycobacterium tuberculosis Erdman (250–500 CFU, bronchoscopically), respectively. Whole blood (†), BAL (‡) and lung (g=P) samples were collected at indicated time points.