Table 1. Tissue distribution of FMDV during the pre-viremic phase of infection following IOP inoculation.
| 6 HPI | 12 HPI | % Positive | Mean GCN | |||||
| Animal ID | 37400 | 37401 | 37896 | 37897 | 37403 | qRT-PCR | VI | |
| Oral cavity/oropharynx | ||||||||
| Tongue- anterior | - | - | 3.04 | - | - | 20 | 0 | 3.04 |
| Lingual tonsil | 3.48 | 3.08 | - | - | 4.96 | 60 | 60 | 3.84 |
| Paraepiglottic tonsil | 3.00 | 4.61 | 3.37 | + | 4.93 | 80 | 100 | 3.98 |
| Tonsil of the soft palate | - | - | 4.00 | - | - | 20 | 20 | 4.00 |
| Nasal cavity/Nasopharynx | ||||||||
| Dorsal soft palate -Rostral | 2.56 | + | - | - | 3.08 | 40 | 40 | 2.82 |
| Dorsal soft palate -Caudal | - | + | - | - | 4.01 | 20 | 40 | 4.01 |
| Nasal turbinates | - | - | - | - | - | 0 | 0 | - |
| Nasopharyngeal tonsil | - | - | - | 0 | 20 | - | ||
| Dorsal nasopharynx | - | - | - | + | 3.42 | 20 | 40 | 3.42 |
| Lungs/Trachea | ||||||||
| Trachea | - | - | - | - | - | 0 | 0 | - |
| Cranial lung | - | - | - | - | - | 0 | 0 | - |
| Mid lung | - | - | - | - | 2.87 | 20 | 0 | 2.87 |
| Caudal lung | - | - | - | - | - | 0 | 0 | - |
| Additional tissues | ||||||||
| Visceral organs* | - | - | - | - | - | 0 | 0 | - |
| Medial Retropharyngeal LN | - | - | - | - | - | 0 | 0 | - |
| Submandibular LN | - | - | - | - | - | 0 | 0 | - |
| Hilar LN | - | - | - | - | - | 0 | 0 | - |
| Popliteal LN | - | - | - | - | - | 0 | 0 | - |
| Adrenal gland | - | - | - | - | - | 0 | 0 | - |
| Bone marrow | - | - | - | - | - | 0 | 0 | - |
| Myocardium | - | - | - | - | - | 0 | 0 | - |
| Psoas Muscle | - | - | - | - | - | 0 | 0 | - |
| Semimembraneous muscle | - | - | - | - | - | 0 | 0 | - |
| Shoulder Muscle | - | - | - | - | - | 0 | 0 | - |
| Neck skin | - | - | - | - | - | 0 | 0 | - |
| Snout skin | - | - | - | - | - | 0 | 0 | - |
| Coronary band | - | - | - | - | - | 0 | 0 | - |
Numbers represent Log10 genome copy numbers (GCN)/mg of tissue. Bold numbers indicate that samples were positive for both FMDV RNA (qRT-PCR) and virus isolation, (+) indicates that virus isolation was positive but FMDV RNA content was below the limit of detection, (-) indicates double negative samples. Limit of detection: 2.52 Log10 GCN/mg of tissue.
* Visceral organs included liver, spleen, kidney, pancreas, ileum and Peyer's patches. Other tissues analyzed with consistently negative results were epiglottis, larynx, pharyngeal-diverticulum, salivary glands, adrenal glands, bone marrow.