Table 3.

Association of outcomes with possible untreated hypospadias by severity.

	Normal	Mild untreated hypospadias	pa	Severe untreated hypospadias	pb
PPSc
Length of penis	1.9 (0.7)	1.8 (0.8)	0.7	2.0 (0.7)	0.5
Position and shape of urethral opening	2.4 (0.6)	2.2 (0.5)	0.044	2.1 (0.8)	0.063
Shape of glans	2.4 (0.6)	2.4 (0.6)	0.6	2.2 (0.9)	0.3
Shape of penile skin	2.3 (0.6)	2.4 (0.5)	0.6	2.4 (0.4)	0.1
Penile axis (curvature)	2.3 (0.7)	2.2 (0.8)	0.4	1.7 (1.0)	0.016
General appearance	2.2 (0.7)	2.2 (0.8)	0.9	2.2 (0.6)	0.9
Overall PPS	9.4 (2.0)	9.3 (1.9)	0.6	8.6 (2.3)	0.2
SHIM score	20.7 (5.3)	17.4 (6.2)	0.003	16.1 (6.1)	0.017
IPSS score	5.9 (6.0)	6.5 (7.3)	0.6	10.8 (7.7)	0.004
CDC HRQOL-4
Would you say your general health isd	2.5 (1.0)	2.7 (1.0)	0.2	2.7 (0.9)	0.5
Mean number of physically unhealthy days	3.5 (7.0)	3.5 (6.9)	0.9	9.2 (11.9)	0.003
Mean number of mentally unhealthy days	6.5 (8.7)	6.8 (9.0)	0.8	12.1 (12.4)	0.017
Caused a pregnancy	317/674 (47.0%)	20/37 (54.0%)	0.4	9/14 (64.3%)	0.2
Diagnosis of infertility	22/677 (3.2%)	1/37(2.7%)	0.8	1/15 (6.7%)	0.4
How often to you sit on toilet to just urinate?e	1.9 (1.2)	2.0 (1.3)	0.8	3.1 (1.7)	0.003
Of those who sit to urinate; how much does it bother you to sit down to just urinate?f	1.4(0.7)	1.3 (0.6)	0.7	1.7 (0.8)	0.8
Penile curvatureg	1.8 (0.7)	2.2 (1.1)	0.015	2.3 (1.2)	0.09
How difficult does the curvature of your penis make intercourse?h	4.8 (0.6)	4.5 (1.0)	0.007	4.0 (1.0)	<0.001
Have you ever kissed anyone?	647/676 (95.7%)	36/37 (97.3%)	1.0	14/15 (93.3%)	0.5
Age in years	14.1 (4.5)	13.4(4.2)	0.4	14.9 (3.0)	0.5
Have you ever been in love?	595/674 (88.3%)	32/37 (86.5%)	0.8	15/15 (100%)	0.2
Age in years	18.2 (6.0)	17.3 (6.0)	0.7	18.9 (7.0)	0.7
Have you ever had sexual intercourse?	598/678 (88.2%)	31/35 (88.6%)	1.0	14/15 (93.3%)	1.0
Age in years	18.3 (5.0)	18.3 (6.8)	1.0	16.6 (4.9)	0.2
Have you ever masturbated?	663/678 (97.8%)	34/35 (97.1%)	1.0	15/15 (100%)	1.0
Age in years	12.3 (2.7)	11.6 (2.9)	0.2	11.9 (2.3)	0.6

Data presented as mean (standard deviation) or proportion with “yes” answer. Continuous outcomes compared by student’s t-test, ordinal by Wilcoxon rank sum test, dichotomous by chi-square or Fisher Exact test.

^ap for comparison of normal and mild untreated hypospadias.

^bp for comparison of normal and severe untreated hypospadias.

^cAll questions coded as 3 = very satisfied; 2 = satisfied; 1 = dissatisfied; 0 = very dissatisfied.

^d1 = excellent; 2 = very good, 3 = good, 4 = fair, 5 = poor.

^e1 = Almost never or never; 2 = a few times (much less than half the time); 3 = sometimes (about half the time); 4 = most times (much more than half the time); 5 = almost always or always.

^f1 = not at all bothered; 2 = very little bothered; 3 = moderately bothered; 4 = significantly bothered; 5 = extremely bothered.

^gHigher number corresponds to more ventral curvature. See Fig. 1.

^h1 = did not attempt intercourse; 2 = extremely difficult; 3 = very difficult; 4 = difficult; 5 = slightly difficult; 6 = not difficult.