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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Biometrics. 2014 Mar 3;70(3):579–587. doi: 10.1111/biom.12163

Table 2.

Simulation results for lognormal frailty: AVG, average number of events per subject; SD, sample standard deviation; SE, mean of estimated standard errors; CP, empirical coverage probability of 95% Wald-type confidence interval; RE, relative efficiency of NPMLE compared with GehanR.

NPMLE GehanR
AVG σ2 Bias SD β Bias SD SE CP(%) Bias SD RE
Λ0(t)=log(t + 1)
2 2.320 −0.308 .769 −1 0.052 .491 .469 93.4 −0.001 .730 2.210
1 −0.027 .414 .417 94.6 −0.029 .587 2.010
4 2.320 −0.136 .779 −1 0.046 .398 .460 96.4 0.019 1.085 7.432
1 −0.022 .367 .411 95.8 −0.025 .876 5.697
2 1.718 −0.121 .572 −1 0.055 .475 .464 94.0 0.003 .663 1.948
1 0.04 .406 .415 95.2 −0.022 .556 1.875
4 1.718 −0.045 .523 −1 0.016 .406 .410 94.8 0.015 .985 5.886
1 −0.014 .382 .363 94.0 −0.011 .773 4.095
2 0.649 0.128 .235 −1 0.009 .405 .439 95.4 −0.022 .479 1.399
1 −0.000 .374 .390 95.8 0.009 .414 1.225
4 0.649 0.061 .189 −1 −0.006 .378 .392 95.8 0.001 .692 3.351
1 0.028 .344 .346 94.8 0.012 .575 2.794

Λ0(t)=−log{1 − Φ(log t)}
2 2.320 −0.371 .731 −1 0.045 .329 .309 96.0 −0.015 .413 1.576
1 −0.054 .287 .279 93.2 −0.011 .359 1.565
4 2.320 −0.305 .744 −1 0.052 .337 .337 95.0 −0.009 .506 2.254
1 −0.018 .299 .297 94.2 −0.015 .413 1.908
2 1.718 −0.153 .572 −1 0.009 .293 .282 93.8 −0.019 .377 1.656
1 −0.018 .262 .254 94.4 −0.009 .328 1.567
4 1.718 −0.216 .484 −1 0.052 .286 .292 95.0 −0.009 .451 2.487
1 −0.05 .257 .257 93.6 −0.012 .370 2.073
2 0.649 0.088 .257 −1 −0.009 .281 .272 94.0 −0.02 .296 1.110
1 0.026 .233 .245 96.4 0.005 .244 1.097
4 0.649 −0.011 .177 −1 0.006 .243 .249 95.0 −0.017 .322 1.756
1 −0.012 .215 .222 95.6 0.008 .265 1.519