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HPV-11 suppresses release of IL-36γ from keratinocytes. Human foreskin keratinocytes that had been transduced with either a lentivirus construct expressing all early HPV-11 genes or the empty vector were treated with poly(I:C) or solvent for 96 h. IL-36γ release was measured by ELISA (A), with results shown as the mean ± SD of three assays, *p < 0.05. Comparable levels of intracellular IL-36γ were confirmed by Western blot (B).
