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. 2014 Jul 31;20(1):302–312. doi: 10.2119/molmed.2013.00040

Figure 4.

Figure 4

Diabetes leads to reexpression of fetal genes in adult cardiac tissue. (A) MHC isoform mRNA distribution shown as % of total MHC mRNAs as measured by qPCR. (B) Protein expression of β-MHC isoform and total MHC detected by Western blot. Expression represented as ratio of β-MHC to total MHC expression. (C) Cardiac protein expression of sarcoplasmic reticulum proteins detected by Western blot. (D) Quantitative summary of normalized protein expression. MHC, myosin heavy chain; SERCA2a, sarcoplasmic/endoplasmic reticulum calcium ATPase 2; PLB, phospholamban; p-PLB, phosphorylated phospholamban (site of phosphorylation); n = 4–8/group. *p < 0.05 versus control; †p < 0.05 versus STZ/N.