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. 2014 Aug 18;7:543. doi: 10.1186/1756-0500-7-543

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© Martinez-Chacin et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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BC invasion genes are enriched in HFD microarray samples. Gene set enrichment analysis (GSEA) was performed with microarray data from 10 week old mice treated with HFD (labeled F) or control diet (labeled C) and 361 curated genes sets from the Molecular Signatures Database, Broad Institute; enrichment plots for two of the analyzed gene sets are shown. In these analyses, genes are ranked based on their association with the HFD phenotype or the control phenotype. Genes most strongly associated with HFD would be on the far right. Enrichment scores (ES) are calculated using a weighted Kolmogorov-Smirnov-style statistic. Lines underneath the graph depict the genes that are contained in the investigated gene set. A-B, genes associated with invasion in BC were highly associated with HFD samples. P values are indicated on plots.