Effects of DNMT1 siRNA on cell viability (A), apoptosis (B), colony formation (C) and invading ability of invation (D). a, P<0.05 compared with the untreated cells. b, P<0.05 compared with the negative siRNA transfected cells. The data are shown as the mean ± SD of eight independent experiments. DNMT1, DNA methyltransferase 1.