Table 5. Multivariate analysis of prognostic factors in patients with ccRCC.
| Factor | Overall survival |
Disease-free survival |
|||||
|---|---|---|---|---|---|---|---|
| RR | 95% CI | P | RR | 95% CI | P | ||
| Gender | |||||||
| Male/Female | 1.095 | 0.658-2.927 | 0.742 | 1.253 | 0.720-2.916 | 0.786 | |
| Age, years | |||||||
| >55/≤55 | 1.369 | 0.615-2.874 | 0.613 | 1.387 | 0.584-2.887 | 0.651 | |
| Tumor size, cm | |||||||
| ≤4/>4 | 7.085 | 4.102-13.023 | 0.037 | 7.713 | 4.423-14.018 | 0.027 | |
| Tumor pathology stage | |||||||
| T3-T4/T1-2 | 8.684 | 5.103-14.053 | 0.024 | 8.501 | 5.012-13.958 | 0.023 | |
| Grading | |||||||
| 3,4/1,2 | 3.341 | 2.324-6.573 | 0.021 | 2.896 | 2.021-3.989 | 0.019 | |
| Lymph node metastasis | |||||||
| Yes/no | 3.531 | 2.530-6.604 | 0.017 | 3.701 | 2.672-6.714 | 0.013 | |
| Vascular invasion | |||||||
| Yes/no | 2.437 | 1.987-6.021 | 0.027 | 2.887 | 1.906-5.134 | 0.022 | |
| Tobacco smoking | |||||||
| Yes/no | 1.848 | 0.893-4.283 | 0.593 | 1.659 | 0.993-3.984 | 0.682 | |
| DNMT1 status | |||||||
| Positive/negative | 1.876 | 0.926-2.021 | 0.031 | 1.962 | 1.053-2.416 | 0.213 | |
RR, relative risk; 95% CI, 95% confidence interval; ccRCC, clear cell renal cell carcinoma.