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. 2014 Aug 26;15(1):716. doi: 10.1186/1471-2164-15-716

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© Gao et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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BSP combined with high-throughput HiSeq sequencing for methylation validation. (A) Scatter plots of the average DNA methylation level of all CpG sites covered by both HiSeq-BSP (X-axis) and Sanger-BSP (Y-axis), with each plot indicating a CpG site. A regression line is added and the regression coefficient is indicated. (B) Examples of DMR in the promoter of five genes (CEND1, COX17, CYP2W1, FOXP4 and MAB21L2) with general consistency for methylation levels detected by HiSeq-BSP and Sanger-BSP. (C) An example of DMR in the promoters of CDX1 with greater variability of methylation levels detected by HiSeq-BSP and Sanger-BSP