. 2014 Jun 28;14(3):159–164. doi: 10.1007/s40268-014-0053-9

Table 1.

Pharmacokinetic parameters for omeprazole 40 mg/day given without or with oral icosapent ethyl 4 g/day (pharmacokinetic analysis population, n = 28)

PK Parameter (unit)^a	Treatment
PK Parameter (unit)^a	Omeprazole 40 mg	Icosapent Ethyl 4 g + Omeprazole 40 mg
AUC_0–24 (ng·h/mL)	3,607 (2,208)	3,142 (2,114)
C _max (ng/mL)	1,156 (461)	1,222 (621)
T _max (h)	1.5 (1.0–6.0)	1.5 (0.7–8.0)
t _1/2 (h)	1.5 (0.7)	1.4 (0.7)
K _el (L/h)	0.56 (0.22)	0.62 (0.26)

AUC _0–24 area under the plasma concentration-time curve from time 0 to 24 h, C _max maximum observed concentration, K _el apparent terminal elimination rate constant, PK pharmacokinetic, t _1/2 apparent terminal elimination half-life, T _max time of maximum observed concentration

^aMean (standard deviation) displayed for all PK parameters except T _max, which is displayed as median (minimum–maximum)