Table 2.
PK Parameter (unit) | Statistica | Treatment | |
---|---|---|---|
Omeprazole 40 mg | Icosapent Ethyl 4 g + Omeprazole 40 mg | ||
AUC0–24 (ng·h/mL) | LSGM | 2,973 | 2,484 |
Ratio | 0.84 | ||
90 % CI | 75.99–91.87 | ||
C max (ng/mL) | LSGM | 1,051 | 1,059 |
Ratio | 1.01 | ||
90 % CI | 87.36–116.3 |
AUC 0–24 area under the plasma concentration-time curve from time 0 to 24 h, CI confidence interval, C max maximum observed concentration, LSGM least squares geometric means, PK pharmacokinetic
aLSGM derived from mixed models; LSGM ratios are provided for icosapent ethyl plus omeprazole/omeprazole alone