Table I.
Plasma Octreotide Levels of Cynomoglus Monkeys Orally Dosed for 9-months with 20 mg Octreotide Acetate and Oily Suspension in Enteric-coated Capsules
Sex | PK parameters | Treatment days | ||
---|---|---|---|---|
1 | 180 | 270 | ||
Male | Cmax (ng/mL) | 22 ± 6 | 39 ± 35 | 30 ± 18 |
AUC0-t (h × ng/mL) | 49 ± 13 | 84 ± 74 | 68 ± 40 | |
Female | Cmax (ng/mL) | 15 ± 4 | 13 ± 3 | 42 ± 14 |
AUC0-t (h × ng/mL) | 34 ± 9 | 28 ± 7 | 92 ± 31 | |
Total | Cmax (ng/mL) | 19 ± 4 | 26 ± 13 | 36 ± 11 |
AUC0-t (h × ng/mL) | 42 ± 8 | 56 ± 29 | 80 ± 25 |
Results expressed as arithmetic mean ± SE (n = 5 per gender)