Table 3.

Primary Study Outcomes

	28 Day Mortality OR (95% CI) p-value *	24 Hour Mortality OR (95% CI) p-value *	6 Month GOSE <=4 OR (95% CI) p-value *
Volume (per 500 people increase)
All Patients	0.93 (0.89, 0.97) 0.002	0.93 (0.88, 0.99) 0.027
Shock Cohort	0.94 (0.88, 1.01) 0.100	0.94 (0.88, 1.02) 0.132
TBI only Cohort	0.93 (0.89, 0.98) 0.003	0.94 (0.88, 1.01) 0.068	0.92 (0.87, 0.98) 0.011
Trauma Level (I versus II)
All patients	0.77 (0.54, 1.10) 0.148	0.75 (0.47, 1.21) 0.241
Shock Cohort	0.45 (0.23, 0.89) 0.023	0.55 (0.27, 1.13) 0.104
TBI only Cohort	1.04 (0.70, 1.56) 0.837	0.55 (0.22, 1.37) 0.199	1.31 (0.90, 1.91) 0.162
Volume and Designation Level in same Model
All Patients: Volume	0.93 (0.88, 0.98) 0.004	0.93 (0.87, 0.99) 0.030
All Patients: Trauma Level I	0.97 (0.64, 1.46) 0.870	1.01 (0.63, 1.62) 0.974
Shock Cohort: Volume	0.98 (0.92, 1.04) 0.551	0.96 (0.90, 1.04) 0.310
Shock Cohort: Trauma Level I	0.46 (0.23, 0.94) 0.032	0.67 (0.31, 1.43) 0.297
TBI only Cohort: Volume	0.91 (0.87, 0.96) 0.001	0.92 (0.87, 0.98) 0.013	0.89 (0.84, 0.95) <0.001
TBI only Cohort: Trauma Level I	1.40 (0.88, 2.22) 0.152	1.46 (0.76, 2.80) 0.262	1.87 (1.16, 3.02) 0.010

OR=Odds Ratio; CI=Confidence Interval

Adjustment Factors: age, sex, lowest PH SBP, PH GCS, transportation mode, use of advanced airway, PH time, mechanism of injury, ISS, initial ED SBP, head AIS