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. Author manuscript; available in PMC: 2014 Sep 4.
Published in final edited form as: Stem Cell Res. 2013 Jan 29;10(3):361–370. doi: 10.1016/j.scr.2013.01.006

Figure 3.

Figure 3

Mutational hot spots of the mtDNA control region in single CD34+ cells and in reported complete mtDNAs from worldwide populations. Mutational hot spots were scored, according to their occurrences in the respective individual, but with disregarding their frequencies in a cell population from the individual. As the number of donors in each family varied, we arbitrarily regarded a certain site as a mutational hot spot if mutations hit the site at least in 3 donors in 18 unrelated healthy individuals (A), 2 donors in Family A (N=6) (C), and 4 donors in Family B (N=16) (D). The 18 unrelated healthy individuals included one member (C-2) of Family C in addition to 17 unrelated donors (14 reported healthy individuals (Ogasawara et al., 2005; Yao et al., 2007b; Yao et al., 2007d) and three cord blood donors). The mutational hot spots in worldwide mtDNAs are listed (B) when mutations appear at least 30 times in the global tree of 2196 complete mtDNA sequences (Soares et al., 2009).