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. 2014 Jun 13;99(9):3399–3407. doi: 10.1210/jc.2014-1982

Table 3.

HR-pQCT Measurements of the Radius and Tibia in Subjects With CF and Healthy Volunteersa

CF Healthy Volunteers Mean Percent Differenceb Unadjusted P Value BMI-Adjusted P Value BMI- and aBMD-Adjusted P Value
DXA aBMD, g/cm2
    Total hip 0.870 ± 0.024 1.034 ± 0.017 −15.9 <.001 .007
    Femoral neck 0.770 ± 0.024 0.936 ± 0.017 −17.7 <.001 .004
    PA spine 0.973 ± 0.022 1.069 ± 0.016 −9.0 .001 .31
    Whole body 0.970 ± 0.018 1.071 ± 0.014 −9.4 <.001 .042
    Percent fat mass 25.9 ± 0.9 28.8 ± 0.7 −10.3 .011
Radius
    Density, mg HA/cm3
        Total vBMD 303.2 ± 8.4 332 ± 5.9 −8.7 .007 .27 .98
        Cort vBMD 941.3 ± 5.0 952.6 ± 3.5 −1.2 .068 .68 .86
        Trab vBMD 165.7 ± 5.5 186.7 ± 3.9 −11.3 .003 .08 .66
    Area, mm2
        Total area 263.9 ± 9.1 300.4 ± 6.4 −12.1 .002 .021 .21
        Cort area 52.0 ± 1.7 61.6 ± 1.2 −15.6 <.001 .025 .43
        Trab area 214.6 ± 8.9 241.7 ± 6.3 −11.2 0.015 .046 .25
    Cort structure
        Cort thickness, mm 0.823 ± 0.027 0.903 ± 0.019 −8.8 .021 .50 .81
        Cort porosity, % 1.07 ± 0.13 1.31 ± 0.09 −18.0 .14 .06 .22
    Trab structure
        Trab thickness, mm 0.068 ± 0.001 0.076 ± 0.001 −9.8 .001 .011 .15
        Trab number, mm−1 2.00 ± 0.04 2.06 ± 0.03 −2.7 .30 .83 .39
        Trab separation, mm 0.44 ± 0.01 0.42 ± 0.01 +5.2 .14 .81 .31
        SD Trab distribution, μm 0.18 ± 0.01 0.17 ± 0.01 +5.6 .33 .87 .31
Tibia
    Density, mg HA/cm3
        Total vBMD 286.3 ± 7.6 334.1 ± 5.3 −14.3 <.001 .002 .022
        Cort vBMD 934.9 ± 6.9 958.6 ± 4.9 −2.5 .007 .13 .16
        Trab vBMD 158.7 ± 5.0 202.9 ± 3.6 −21.8 <.001 <.001 <.001
    Area, mm2
        Total area 650.2 ± 23.8 739.3 ± 16.9 −12.1 .003 .08 .55
        Cort area 109.3 ± 3.7 126.5 ± 2.6 −13.6 <.001 .15 .65
        Trab area 544.7 ± 22.8 616.6 ± 17.2 −11.7 .013 .10 .58
    Cort structure
        Cort thickness, mm 1.19 ± 0.04 1.26 ± 0.03 −5.9 .10 .88 .62
        Cort porosity, % 3.61 ± 0.33 2.96 ± 0.23 +21.9 .11 .22 .24
    Trab structure
        Trab thickness, mm 0.076 ± 0.002 0.0825 ± 0.002 −7.3 .025 .017 .07
        Trab number, mm−1 1.71 ± 0.05 2.06 ± 0.034 −16.7 <.001 .001 .024
        Trab separation, mm 0.52 ± 0.01 0.42 ± 0.01 +24.4 <.001 <.001 .010
        SD Trab distribution, μm 0.23 ± 0.01 0.18 ± 0.01 +25.9 <.001 .040 .35

Abbreviations: aBMD, areal BMD; Cort, cortical; Trab, trabecular.

a

Data are expressed as mean ± SE. Unadjusted group means are presented along with P values for the unadjusted analyses, BMI-adjusted analyses, and BMI- and total hip aBMD-adjusted analyses.

b

Healthy volunteers as reference.