Fig. 1.

PKCε is activated in the early stage of cerulein-induced pancreatitis. Wild-type (WT) mice received intraperitoneal (IP) injections of cerulein (CR) or saline. The pancreata were collected in 15, 30, and 45 min after the cerulein injection. The catalytic activity of PKCε immunoprecipitated from pancreatic tissue lysates was determined by in vitro kinase assay. Values (means ± SE, n = 3 for each condition) were compared with their basal activity in the animals injected with saline. **P < 0.01 or *P < 0.05 vs. saline control.