Table 2.
Demographics, psychosomatic scores and quantitative measurements of the 3 groups of participants
| IBS-C | Healthy Controls | IBS-D | P Value | |
|---|---|---|---|---|
| N | 30 | 30 | 64 | |
| Gender, female/male | 30/0 | 22/8 | 59/5 | |
| Age, yr | 44.6 ± 1.1 | 39.3 ± 2.1 | 41.9 ± 1.5 | 0.161 |
| BMI, kg/m2 | 26.6 ± 0.8 | 25.4 ± 0.7 | 29.7 ± 0.9 | 0.013 |
| Anxiety score (HAD) | 2.8 ± 0.5 | 2.1 ± 0.3 | 4.0 ± 0.5 | 0.117 |
| Depression score (HAD) | 0.9 ± 0.2 | 0.4 ± 0.1 | 1.6 ± 0.2 | 0.0005 |
| Psychosomatic symptom score | 0.4 ± 0.06 | 0.2 ± 0.04 | 0.5 ± 0.04 | <0.0001 |
| Bowel function | ||||
| No. of BM/day | 0.85 ± 0.1 | 1.18 ± 0.1 | 2.26 ± 0.1 | <0.0001 |
| BM form | 2.86 ± 0.2 | 3.77 ± 0.1 | 4.76 ± 0.1 | <0.0001 |
| Quantitative traits | ||||
| Fecal fat, g/day | 5.1 ± 0.9 | 6.6 ± 0.8 | 9.1 ± 0.9 | 0.007 |
| Serum C4, ng/ml | 23.5 ± 4.4 | 25.3 ± 3.1 | 34.7 ± 3.6 | 0.019 |
| Serum FGF-19, pg/ml | 134.9 ± 18.4 | 171.6 ± 25.0 | 118.8 ± 10.8 | 0.051 |
| Total fecal bile acid, mM | 579 ± 161 | 957 ± 185 | 2495 ± 382 | <0.0001 |
| Mean% fecal LCA/CDCA/DCA/CA/UDCA | 49/1/48/2/1 | 39/1/59/1/1 | 30/6/53/8/4 | <0.001 except DCA P = 0.033 |
| Gastric emptying T1/2, min | 117.3 ± 5.0 | 120.0 ± 5.7 | 124.7 ± 3.8 | 0.51 |
| Colonic filling at 6 h,% | 55.0 ± 5.5 | 54.1 ± 4.3 | 55.2 ± 3.4 | 0.92 |
| Colonic transit GC24 | 2.34 ± 0.2 | 2.41 ± 0.2 | 2.85 ± 0.2 | 0.13 |
| Colonic transit GC48 | 3.22 ± 0.17 | 3.86 ± 0.17 | 4.18 ± 0.12 | 0.0001 |
| Urine mannitol 0–2 h | 264.8 ± 42.9 | 355.2 ± 49.5 | 444.3 ± 75.2 | 0.039 |
| Urine mannitol 8–24 h | 65.8 ± 16.1 | 43.6 ± 4.2 | 45.5 ± 5.0 | 0.708 |
Values are means ± SE. Kruskal-Wallis test was used to assess the associations of quantitative traits in the 3 groups. Percentages of individual bile acids rounded to the closest whole number.
IBS-C; IBS-predominant constipation; IBS-D, IBS-predominant diarrhea; HAD, Hospital Anxiety and Depression Scale; BM, bowel movements; C4, 7 α-hydroxy-4-cholesten-3-one; LCA, lithocholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; CA, cholic acid; UDCA, ursodeoxycholic acid; ns, not significant.