Table 6.
Univariate associations of responses with genotype
| Candidate Genotype and Associated P Value for Symptom or Quantitative Trait |
|||||
|---|---|---|---|---|---|
| Symptoms and Phenotype | GPBAR1 | KLB | FGFR4 | SLC6A4 | TNFSF15 |
| Gene SNP or Variant | rs11554825 | rs17618244 | rs351855 | rs4795541 | rs4263839 |
| Symptom phenotype (IBS-C or D, or healthy) (n = ∼124) | 0.045 | 0.734 | 0.007 | 0.060 | 0.382 |
| HAD score anxiety | 0.055 | 0.379 | 0.175 | 0.959 | 0.913 |
| HAD score depression | 0.965 | 0.068 | 0.050 | 0.554 | 0.654 |
| Psychosomatic symptom score | 0.375 | 0.333 | 0.008 | 0.994 | 0.113 |
| Mean no. of stools | 0.098 | 0.254 | 0.722 | 0.090 | 0.168 |
| Mean stool consistency | 0.441 | 0.327 | 0.851 | 0.042 | 0.396 |
| Mean ease of stool passage | 0.122 | 0.246 | 0.424 | 0.039 | 0.215 |
| Mean proportion of incomplete evacuations | 0.429 | 0.295 | 0.003 | 0.927 | 0.516 |
| Fat and bile binetics (n = ∼124) | |||||
| Serum FGF19 (pg/ml | 0.178 | 0.743 | 0.060 | 0.171 | 0.855 |
| Serum C4, ng/ml | 0.100 | 0.891 | 0.838 | 0.827 | 0.342 |
| Total fecal bile acid, mM | 0.030 | 0.547 | 0.519 | 0.038 | 0.131 |
| Total fecal fat (g/24 h) | 0.776 | 0.521 | 0.800 | 0.334 | 0.113 |
| Transit data (n = ∼124) | |||||
| GE T½, min | 0.035 | 0.750 | 0.656 | 0.735 | 0.379 |
| Colon GC 24 h | 0.114 | 0.334 | 0.672 | 0.403 | 0.958 |
| Colon GC 48 h | 0.003 | 0.274 | 0.840 | 0.384 | 0.869 |
| Ascending colon T½, h | 0.049 | 0.341 | 0.366 | 0.421 | 0.631 |
| Permeability data (n = ∼117) | |||||
| Mannitol excretion (0–2 h) | 0.569 | 0.364 | 0.957 | 0.555 | 0.296 |
| Mannitol excretion (8–24 h) | 0.381 | 0.859 | 0.873 | 0.837 | 0.755 |
| L:M ratio (0–2 h) | 0.682 | 0.908 | 0.714 | 0.734 | 0.706 |
| L:M ratio (8–24 h) | 0.674 | 0.399 | 0.779 | 0.622 | 0.442 |
P values are based on Kruskal-Wallis test, Fisher's exact test (symptom phenotype) assuming the 2° of freedom general genetic model. L:M, lactulose-to-mannitol ratio; GET½, gastric emptying half time.