Table 7.

Estimated post hoc power (%) for GPBAR1, KLB, and SLC6A4

SNP	GPBAR1 rs11554825	KLB rs17618244	SLC6A4 rs4795541
Allele frequencies	C: 42.2%; T: 57.8%	A: 19%; G: 81%	S: 43%; L: 57%
Colon transit GC @24 h	84%	37%	59%
Colon transit GC @48 h	80%	48%	74%
Total fecal BA	61%	11%	17%

Values were determined by 1-way ANOVA, α = 0.05, overall SNP effect. In this analysis, it was assumed that the colonic transit between genotypes for each SNP would differ by 0.5 GC units (e.g., GC24 h values of 2.4, 2.9, and 3.4) and total fecal BA values by 800 mM (e.g., 957, 1,757, and 2,557 mM). The minor allele frequencies are based on prior studies from our laboratory in 695 people (patients with IBS and healthy controls, who had similar ethnicity and race to the participants in the present study) for the specific genetic variants in GPBAR1 and KLB and 626 people for SLC6A4.