Table 3. Associations between demographic, laboratory variables and genetic variants with CBFv as a continuous measurementa.
| Predictors | β‐Coefficient (95% CI) | P‐value | Observations (n) |
|---|---|---|---|
| Age (years)b | −2·28 (−3·21 to −1·35) | <0·0001 | 525 |
| Sex (male vs female)b | 3·512 (−3·56–10·58) | 0·329 | 525 |
| Haemoglobin (g/l)b | −4·60 (−7·91 to−1·29) | 0·007 | 525 |
| Fetal haemoglobin (%)b | −0·197 (−1·11–0·72) | 0·672 | 525 |
| Haptoglobin HP11c | |||
| HP12 | 0·28 (−9·61–10·17) | 0·956 | 410 |
| HP22 | −2·994 (−15·32–9·33) | 0·633 | |
| α‐Thalassaemia normalc | |||
| 1 Deletion | −6·32 (−13·78–1·14) | 0·097 | 549 |
| 2 Deletions | −16·14 (−26·271 to −6·0135) | 0·002 | |
| G6PD Phenotype normalc | |||
| Mild (A‐B) | −8·80 (−19·44–1·84) | 0·105 | 564 |
| Affected (A‐Z or A‐A‐) | −1·81 (−11·83–8·21) | 0·723 | |
a
Only velocity values >0 cm/s included for multiple linear regression.
b
Results for multivariable regression including the marked variables.
c
Adjusted for age and survey year CBFv, cerebral blood flow velocity; 95% CI, 95% confidence interval.