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. 2014 Jul 3;6(8):995–1002. doi: 10.15252/emmm.201403959

Figure 1. TORC2 complex signaling to AGC kinases.

Figure 1

Shown is a summary of TORC2 in human, S. cerevisiae and S. pombe. The human proteins Rictor and Sin1 are TORC2-specific subunits conserved in both yeast species, being known as Avo3 (Rictor) and Avo1 (Sin1) in S. cerevisiae (Loewith et al, 2002) or Ste20 (Rictor) or Sin1 in S. pombe (Hayashi et al, 2007; Matsuo et al, 2007). The target kinases of TORC2 are AKT1 (Sarbassov et al, 2005), SGK1 (Garcia-Martinez & Alessi, 2008), PKC-α (Facchinetti et al, 2008; Ikenoue et al, 2008), and PKC-ζ (Li & Gao, 2014) in higher eukaryotes, while they are Ypk1 and Ypk2 (Kamada et al, 2005), and the PKC ortholog Pkc1 (Facchinetti et al, 2008) in budding yeast. Fission yeast has only one identified AGC-kinase, Gad8 (Matsuo et al, 2003).