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. 2014 Jul 7;6(8):1003–1015. doi: 10.15252/emmm.201404044

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© 2014 The Authors. Published under the terms of the CC BY 4.0 license

This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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A   Mbd5^+/GT mice have decreased grip strength than Mbd5^+/+controls.

B   Mbd5^+/GT mice were less capable than Mbd5^+/+ mice to hang from an elevated wire with their forepaws.

C Mbd5^+/GT displayed impaired motor coordination compared with Mbd5^+/+ mice on the dowel test. Mbd5^+/GT mice reach the platform less times (arrivals) and fell of the dowel more frequently than Mbd5^+/+ mice.

D   Performance on the accelerating rotarod is deficient in Mbd5^+/GT compared with Mbd5^+/+ over all trials (6-week-old male mice, n = 9 Mbd5^+/+ and n = 16 Mbd5^+/GT; Student's t-test; unpaired, two-tailed distribution, P-values are displayed above the bars in the figure).