. Author manuscript; available in PMC: 2014 Sep 4.

Published in final edited form as: J Ren Nutr. 2012 Oct 6;23(4):288–295.e1. doi: 10.1053/j.jrn.2012.08.009

Table 3.

Adjusted time-updated associations between altered taste perception and nutritional indices as well as components of the malnutrition-inflammation-cachexia syndrome overall and stratified on self-reported alteration in appetite.^*

	Adjusted mean difference comparing altTP to nlTP
	Overall (n=5124 pt-yrs)	No self-reported appetite impairment (n=1367 pt-yrs)	With self-reported appetite impairment (n=3757 pt-yrs)
Normalized protein catabolic rate	−0.05 +/− 0.01 <0.001	−0.05 +/− 0.02 0.01	−0.04 +/− 0.01 <0.001
Normalized protein catabolic rate	−0.05 +/− 0.01 <0.001	p-interaction=0.83
Reported caloric intake; kcal/kg/d	−0.54 +/− 0.31 0.08	−0.71 +/− 0.66 0.29	−0.33 +/− 0.33 0.32
Reported caloric intake; kcal/kg/d	−0.54 +/− 0.31 0.08	p-interaction=0.43
Reported protein intake; g/kg/d	−0.04 +/− 0.01 0.006	−0.03 +/− 0.03 0.31	−0.03 +/− 0.01 0.04
Reported protein intake; g/kg/d	−0.04 +/− 0.01 0.006	p-interaction=0.90
Reported sodium intake; mg/day	−90 +/− 40 0.02	−150 +/− 80 0.05	−50 +/− 40 0.23
Reported sodium intake; mg/day	−90 +/− 40 0.02	p-interaction=0.19
Interdialytic weight gain; kg	−0.04 +/− 0.04 0.38	+ 0.08 +/− 0.09 0.34	−0.05 +/− 0.05 0.32
Interdialytic weight gain; kg	−0.04 +/− 0.04 0.38	p-interaction=0.26
Estimated dry weight; kg	−1.03 +/− 0.58 0.08	−0.48 +/− 1.16 0.68	−0.70 +/− 0.61 0.25
Estimated dry weight; kg	−1.03 +/− 0.58 0.08	p-interaction=0.88
Midarm muscle circumference; cm	−0.28 +/− 0.14 0.05	−0.14 +/− 0.31 0.66	−0.23 +/− 0.15 0.14
Midarm muscle circumference; cm	−0.28 +/− 0.14 0.05	p-interaction=0.93
Triceps skinfold thickness; mm	−0.68 +/− 0.44 0.12	−0.57 +/− 0.88 0.52	−0.43 +/− 0.46 0.35
Triceps skinfold thickness; mm	−0.68 +/− 0.44 0.12	p-interaction=0.91
Serum albumin; g/dL	−0.03 +/− 0.01 0.02	−0.05 +/− 0.02 0.04	−0.02 +/− 0.01 0.21
Serum albumin; g/dL	−0.03 +/− 0.01 0.02	p-interaction=0.35
Serum creatinine; mg/dL	−0.22 +/− 0.08 0.009	−0.26 +/− 0.17 0.13	−0.10 +/− 0.09 0.27
Serum creatinine; mg/dL	−0.22 +/− 0.08 0.009	p-interaction=0.30
Serum phosphorus; mg/dL	+0.05 +/− 0.06 0.44	+0.11 +/− 0.13 0.41	+0.05 +/− 0.07 0.49
Serum phosphorus; mg/dL	+0.05 +/− 0.06 0.44	p-interaction=0.61
Serum bicarbonate; mEq/L	+0.07 +/− 0.13 0.61	+0.03 +/− 0.27 0.91	−0.03 +/− 0.15 0.82
Serum bicarbonate; mEq/L	+0.07 +/− 0.13 0.61	p-interaction=0.77
Serum intact PTH; pg/mL	−33 +/− 12 0.007	−1 +/− 25 0.97	−39 +/− 14 0.004
Serum intact PTH; pg/mL	−33 +/− 12 0.007	p-interaction=0.32
White blood count; K/uL	+0.09 +/− 0.08 0.26	−0.20 +/− 0.16 0.22	+0.16 +/− 0.09 0.07
White blood count; K/uL	+0.09 +/− 0.08 0.26	p-interaction=0.03
Hematocrit; %	+0.14 +/− 0.14 0.35	+0.61 +/− 0.29 0.03	+0.10 +/− 0.16 0.55
Hematocrit; %	+0.14 +/− 0.14 0.35	p-interaction=0.10
Ferritin; ng/mL	+42 +/− 17 0.02	+14 +/− 27 0.56	+39 +/− 20 0.05
Ferritin; ng/mL	+42 +/− 17 0.02	p-interaction=0.54
TIBC; ug/dL	−1.7 +/− 2.0 0.38	−0.2 +/− 3.8 0.96	−1.6 +/− 2.2 0.47
TIBC; ug/dL	−1.7 +/− 2.0 0.38	p-interaction=0.75

All analyses adjusted for age, sex, race, vintage, access type, and diabetes, congestive heart failure, ischemic heart disease, cerebrovascular disease, and peripheral vascular disease; variance estimates adjusted for within-subject clustering. Negative coefficients indicate a lower value for altTP relative to nlTP. P-interaction measures the significance of the difference in effect estimates between subjects with normal appetite versus those with impaired appetite.