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. 2014 Jul 22;28(9):1408–1422. doi: 10.1210/me.2014-1074

Figure 1.

Figure 1.

Steroid-mediated glandular epithelial-luminal epithelial-stromal cross talk in the uterus. E induces LIF in the glandular epithelium (blue), which acts in a paracrine manner on the luminal epithelium (purple) to activate the JAK/STAT pathway to mediate a shift in junctional integrity required for implantation. Activation of JAK/STAT also promotes proliferation of the stroma (pink) via expression and secretion of EGF family proteins from the luminal epithelium. Dashed lines represent indirect events. LIFR, LIF receptor; EGFR, EGF receptor.