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Steroid-mediated epithelial-stromal cross talk in the uterus. Before implantation, E, acting through ESR1 in the stroma (pink), drives epithelial (purple) proliferation through the secretion of paracrine acting FGFs. During the periimplantation period, P, acting on PGR in the stroma, promotes the expression of HAND2. HAND2 inhibits expression of FGFs and blocks E-induced epithelial proliferation. Dashed lines represent indirect events. FGFR, FGF receptor.
