Figure 3.

E2-repressed genes are enriched for transient ER binding events. A, Histogram shows the distribution of differential gene expression by GRO-seq for genes that are closest to early ER peaks (transparent blue) and genes closest to 40-minute peaks (transparent red). B, We plot the fraction of the ER ChIP peaks for each category that are maximally intense at each time point. Note that the distributions of unregulated and activated genes are similar and that repressed genes are enriched for peaks that are maximal at early time points. C, We plotted the ratio of the fraction of the repressed genes to either the fraction of activated (left-most panel) or unregulated (right-most panel) genes, for each kinetic time point.