Table 2.
Upregulated genes in gestational salt-stressed BdkrB2−/− relative to BdkrB2+/+ mice
| Gene Symbol | Entrez ID | Entrez Gene Name | Molecular Function | P Value |
|---|---|---|---|---|
| NCAPG2 | 76044 | nonSMC condensin II complex, subunit G2 | mitotic chromosome assembly and segregation | 3.22E-09 |
| MYH8 | 17885 | myosin, heavy chain 8, skeletal muscle, perinatal | structural constituent of muscle | 4.14E-02 |
| FBLN5 | 23876 | fibulin 5 | cell adhesion; cell-matrix adhesion | 4.03E-06 |
| PLAC9 | 100039175 | placenta-specific 9 | extracellular region | 7.04E-03 |
| ACTC1 | 11464 | actin, alpha, cardiac muscle 1 | actin filament-based movement | 1.84E-02 |
| MYOD1 | 17927 | myogenic differentiation 1 | myogenic factors, muscle regeneration | 2.34E-02 |
| RPL31 | 114641 | ribosomal protein L31 | Ribosomes, component of the 60S subunit | 3.32E-03 |
| FNDC1 | 68655 | fibronectin type III domain containing 1 | extracellular region | 4.47E-02 |
| CNN1 | 12797 | calponin 1, basic, smooth muscle | calmodulin binding, muscle contraction | 4.85E-02 |
| POP4 | 66161 | processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) | processing of precursor RNAs, alternative splicing | 4.85E-02 |
| TEX14 | 83560 | testis expressed 14 | protein amino acid phosphorylation | 2.99E-02 |
| CRIP1 | 12925 | cysteine-rich protein 1 (intestinal) | zinc ion binding, cell proliferation | 2.03E-02 |
| LUM | 17022 | lumican | regulate collagen fibril organization, epithelial cell migration | 3.44E-02 |
| PRELP | 116847 | proline/arginine-rich end leucine-rich repeat protein | extracellular matrix, skeletal system development | 2.51E-02 |
| NRXN1 | 18189 | neurexin 1 | cell adhesion molecules and receptors | 1.36E-03 |
| CD4 | 12504 | CD4 molecule | membrane glycoprotein of T lymphocytes | 1.65E-03 |
| KDM6A | 22289 | lysine (K)-specific demethylase 6A | demethylation of tri/dimethylated histone H3 | 4.47E-02 |
| ACTG2 | 11475 | actin, gamma 2, smooth muscle, enteric | muscle contraction | 4.42E-02 |
| CLEC2D | 232409 | C-type lectin domain family 2, member D | natural killer cell receptor C-type lectin family | 2.47E-02 |
| CLMN | 94040 | calmin (calponin-like, transmembrane) | actin binding | 6.17E-04 |
| WNT1 | 22408 | wingless-type MMTV integration site family, member 1 | signal transducer activity; frizzled binding, transcription activator activity | 2.47E-02 |
| MYH11 | 17880 | myosin, heavy chain 11, smooth muscle | smooth muscle myosin, muscle contraction | 4.06E-02 |
| COL12A1 | 12816 | collagen, type XII, alpha 1 | modify the interactions between collagen I fibrils | 3.62E-04 |
| FGF7 | 14178 | fibroblast growth factor 7 | type 2 fibroblast growth factor receptor binding | 1.94E-02 |
| GPRC5D | 93746 | G protein-coupled receptor, family C, group 5, member D | G protein-coupled receptor, undiscovered function | 3.45E-02 |
| KDM5C | 20591 | lysine (K)-specific demethylase 5C | chromatin modification; regulation of transcription | 2.84E-03 |
| SVEP1 | 64817 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | chromatin binding; calcium ion binding, cell adhesion | 1.53E-02 |
| AHNAK | 66395 | AHNAK nucleoprotein | protein binding, nervous system development | 4.75E-02 |
| ANXA8 | 11752 | annexin A8 | Anticoagulant, inhibits the thromboplastin-specific complex | 3.94E-02 |
| DCN | 13179 | decorin | component of connective tissue, binds to type I collagen fibrils | 2.35E-03 |
| CCBP2 | 59289 | chemokine binding protein 2 | beta chemokine receptor, development and growth of vascular tumors | 4.06E-02 |
| GPR116 | 224792 | G protein-coupled receptor 116 | G-protein coupled receptor | 1.02E-02 |
| CALM1 | 640703 | calmodulin 1 (phosphorylase kinase, delta) | calcium-binding protein, neurogenesis | 2.14E-02 |
| PRSS35 | 244954 | protease, serine, 35 | Trypsin, proteolysis, | 5.50E-03 |
| MATN2 | 17181 | matrilin 2 | formation of filamentous networks | 8.52E-04 |
| COL6A3 | 12835 | collagen, type VI, alpha 3 | type VI collagen, cell adhesion in muscle | 1.71E-02 |
| ELN | 13717 | elastin | elastic fibers, extracellular matrix | 3.09E-02 |
| F13A1 | 74145 | coagulation factor XIII, A1 polypeptide | blood coagulation; peptide cross-linking | 3.09E-03 |
| ARSI | 545260 | arylsulfatase family, member I | cell signaling, and degradation of macromolecules | 2.10E-02 |
| BCAT2 | 12036 | branched chain amino-acid transaminase 2, mitochondrial | branched chain family amino acid biosynthesis | 4.48E-02 |
| VWF | 22371 | von Willebrand factor | platelet-vessel wall mediator | 7.62E-03 |
| ADAMTS5 | 23794 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | metalloendopeptidase activity, proteolysis | 1.03E-03 |
| SPON2 | 100689 | spondin 2, extracellular matrix protein | cell adhesion; axon guidance | 1.55E-03 |
| AKAP12 | 83397 | A kinase (PRKA) anchor protein 12 | adenylate cyclase binding, cAMP biosynthesis | 6.99E-03 |
| CRIM1 | 50766 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | interact with growth factors, implicated in motor neuron differentiation and survival | 6.42E-03 |
| EGFR | 13649 | epidermal growth factor receptor | activation of MAPKK activity; cell morphogenesis | 4.22E-02 |
| FLT1 | 14254 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | VEGFR family, receptor tyrosine kinases, angiogenesis and vasculogenesis | 1.62E-02 |
| WNT2 | 22413 | wingless-type MMTV integration site family member 2 | secreted signaling proteins, regulation of cell fate and patterning during embryogenesis | 2.07E-02 |
| ITPR2 | 16439 | inositol 1,4,5-triphosphate receptor, type 2 | ion channel activity, response to hypoxia | 2.50E-02 |
| SLIT3 | 20564 | slit homolog 3 (Drosophila) | calcium ion binding, organ morphogenesis | 4.88E-03 |
| CDK6 | 12571 | cyclin-dependent kinase 6 | G1 phase of mitotic cell cycle, cell-matrix adhesion | 1.12E-02 |
| MYLK | 107589 | myosin light chain kinase | phosphorylates myosin regulatory light chains | 1.65E-02 |
| COL1A2 | 12843 | collagen, type I, alpha 2 | extracellular matrix, skeletal system development | 4.80E-02 |
| CAV1 | 12389 | caveolin 1, caveolae protein, 22 kDa | coupling integrins to the Ras-ERK pathway and promoting cell cycle progression | 4.13E-02 |
| STARD9 | 668880 | StAR-related lipid transfer (START) domain containing 9 | microtubule motor activity, microtubule-based movement | 3.00E-02 |
| DSP | 109620 | desmoplakin | intercellular junctions, cell-cell adhesion | 5.78E-03 |
| LTBP4 | 108075 | latent transforming growth factor beta binding protein 4 | transforming growth factor beta receptor activity, regulation of cell growth | 1.36E-03 |
| RB1 | 19645 | retinoblastoma 1 | tumor suppressor gene | 4.78E-02 |
| FOXP2 | 114142 | forkhead box P2 | orkhead/winged-helix (FOX) family of transcription factors. | 2.47E-02 |
| FBLN1 | 14114 | fibulin 1 | incorporated into fibrillar extracellular matrix | 1.94E-02 |
| ITPR1 | 16438 | inositol 1,4,5-triphosphate receptor, type 1 | intracellular receptor for inositol 1,4,5-trisphosphate, response to hypoxia | 1.99E-02 |
| THBS1 | 21825 | thrombospondin 1 | adhesive glycoprotein, angiogenesis | 5.50E-03 |
| ABCC9 | 20928 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | ATP-binding cassette (ABC) transporters, multi-drug resistance, | 3.01E-02 |
| NBEA | 26422 | neurobeachin | Target protein kinase A to specific subcellular sites | 4.85E-02 |
| LPP | 210126 | LIM domain containing preferred translocation partner in lipoma | protein binding, cell-cell adhesion and cell motility, transcriptional co-activator | 2.00E-02 |
| NFIA | 18027 | nuclear factor I/A | cellular transcription factors | 1.16E-02 |
| NAV3 | 260315 | neuron navigator 3 | ATPases associated with cellular activities | 6.52E-03 |
| COL3A1 | 12825 | collagen, type III, alpha 1 | type III collagen, cell-matrix adhesion | 1.02E-02 |
| RUNX2 | 12393 | runt-related transcription factor 2 | RUNX family of transcription factors, | 2.55E-02 |
| TNS1 | 21961 | tensin 1 | protein binding, focal adhesions, | 7.76E-03 |
| WISP1 | 22402 | WNT1 inducible signaling pathway protein 1 | a member of the WNT1 inducible signaling pathway (WISP) protein subfamily | 3.94E-02 |
| ADH1A | 0 | alcohol dehydrogenase 1A (class I), alpha polypeptide | alcohol metabolic process; oxidation reduction | 1.79E-02 |
| LAMA2 | 16773 | laminin, alpha 2 | mediate the attachment, migration, and organization of cells | 2.09E-06 |
| NID1 | 18073 | nidogen 1 | basement membrane glycoproteins, adhesion | 1.57E-03 |
| PCDH10 | 18526 | protocadherin 10 | cadherin superfamily, cell adhesion | 3.26E-02 |
| PPP2R2B | 72930 | protein phosphatase 2, regulatory subunit B, beta | negative control of cell growth and division, apoptosis | 2.96E-02 |
| SLC24A3 | 94249 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | intracellular calcium homeostasis, | 4.55E-02 |
| MANBA | 110173 | mannosidase, beta A, lysosomal | Lysosomal hydrolase activity, | 4.59E-02 |
| FBLN1 | 14114 | fibulin 1 | extracellular matrix structural constituent | 1.27E-02 |
| FIGF | 14205 | c-fos induced growth factor (vascular endothelial growth factor D) | angiogenesis, lymphangiogenesis, and endothelial cell growth | 4.49E-02 |
| FZD7 | 14369 | frizzled homolog 7 (Drosophila) | receptors for Wnt signaling proteins | 4.16E-03 |
| AGRN | 11603 | agrin | formation of the neuromuscular junction | 1.89E-02 |
| ITPR2 | 16439 | inositol 1,4,5-triphosphate receptor, type 2 | response to hypoxia, inositol 1,4,5-trisphosphate-sensitive calcium-release channel | 2.09E-03 |
| HIPK2 | 15258 | homeodomain interacting protein kinase 2 | interacts with homeodomain transcription factors | 4.45E-02 |
| KLF4 | 16600 | Kruppel-like factor 4 (gut) | transcription factor, mesodermal cell fate determination | 6.44E-03 |
| SIK3 | 70661 | SIK family kinase 3 | protein amino acid phosphorylation | 2.23E-03 |
| CHST3 | 53374 | carbohydrate (chondroitin 6) sulfotransferase 3 | catalyzes the sulfation of chondroitin, nvolved in cell migration and differentiation | 3.45E-02 |
| SLIT2 | 20563 | slit homolog 2 (Drosophila) | GTPase inhibitor activity, metanephros development, ureteric bud developmen | 4.35E-02 |
| COL15A1 | 12819 | collagen, type XV, alpha 1 | adhere basement membranes to underlying connective tissue stroma | 3.84E-02 |
| BACH2 | 12014 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | transcription factor activity, regulation of transcription | 3.09E-02 |
| DMD | 13405 | dystrophin | muscle organ development | 1.19E-03 |
| EMX1 | 13796 | empty spiracles homeobox 1 | transcription factor activity | 3.22E-02 |
| ANTXR1 | 69538 | anthrax toxin receptor 1 | actin cytoskeleton reorganization | 1.27E-02 |
| EDNRA | 13617 | endothelin receptor type A | potent and long-lasting vasoconstriction | 1.37E-02 |
| CELSR1 | 12614 | cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila) | establishment of planar polarity, cell adhesion | 4.45E-02 |
| LRP2BP | 67620 | LRP2 binding protein | protein binding | 8.84E-03 |
| PMP22 | 18858 | peripheral myelin protein 22 | major component of myelin | 1.71E-02 |
| DDX3X | 13205 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked | alteration of RNA secondary structure | 3.38E-03 |
| POSTN | 50706 | periostin, osteoblast specific factor | heparin binding, cell adhesion, | 3.38E-02 |
| PLCG2 | 234779 | phospholipase C, gamma 2 (phosphatidylinositol-specific) | phosphoinositide phospholipase C activity | 4.75E-02 |
| ICAM1 | 15894 | intercellular adhesion molecule 1 | T cell activation, regulation of cell adhesion | 4.32E-02 |
| ITGB4 | 192897 | integrin, beta 4 | cell communication; cell adhesion | 4.62E-02 |
| COL6A1 | 12833 | collagen, type VI, alpha 1 | maintaining the integrity of various tissues | 3.46E-02 |
| TRPM5 | 56843 | transient receptor potential cation channel, subfamily M, member 5 | voltage-gated ion channel activity | 4.14E-02 |
| CALCRL | 54598 | calcitonin receptor-like | regulation of muscle contraction | 3.44E-02 |
| MLL5 | 69188 | myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) | histone methyltransferase activity (H3-K4 specific) | 1.58E-02 |
| FAM46A | 212943 | family with sequence similarity 46, member A | N/A | 2.14E-02 |
| MYOF | 226101 | myoferlin | membrane regeneration and repair | 3.00E-02 |
| SFRP2 | 20319 | secreted frizzled-related protein 2 | putative Wnt-binding site of Frizzled proteins | 2.47E-02 |
| LHFP | 108927 | lipoma HMGIC fusion partner | member of the lipoma HMGIC fusion partner | 7.40E-03 |
| KCNK4 | 16528 | potassium channel, subfamily K, member 4 | voltage-gated ion channel activity | 3.00E-02 |
| ADAMTS15 | 235130 | ADAM metallopeptidase with thrombospondin type 1 motif, 15 | metalloendopeptidase activity, proteolysis | 4.13E-02 |
| TMCC3 | 319880 | transmembrane and coiled-coil domain family 3 | N/A | 4.12E-02 |
| G0S2 | 14373 | G0/G1 switch 2 | Apoptosis, cell cycle | 2.75E-02 |
| RBMS3 | 207181 | RNA binding motif, single stranded interacting protein 3 | c-myc gene single-strand binding protein | 4.06E-02 |
| CD248 | 70445 | CD248 molecule, endosialin | sugar binding | 4.06E-02 |
| FAM107A | 268709 | family with sequence similarity 107, member A | regulation of cell growth | 2.32E-02 |
| PDGFRB | 18596 | platelet-derived growth factor receptor, beta polypeptide | kidney development, positive regulation of cell proliferation | 4.45E-02 |
| NPPC | 18159 | natriuretic peptide precursor C | potent natriuretic, diuretic, and vasodilating activities | 1.84E-02 |
| CGNL1 | 68178 | cingulin-like 1 | motor activity | 3.73E-02 |
| B4GALT1 | 14595 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | type II membrane-bound glycoproteins, epithelial cell development | 2.70E-03 |
| MMRN2 | 105450 | multimerin 2 | extracellular matrix protein | 7.88E-03 |
| ATP7A | 11977 | ATPase, Cu2+ transporting, alpha polypeptide | copper transport across membranes, blood vessel development | 3.17E-03 |
| EMILIN3 | 280635 | elastin microfibril interfacer 3 | proteinaceous extracellular matrix | 2.67E-02 |
| SLC39A1 | 30791 | solute carrier family 39 (zinc transporter), member 1 | transmembrane transport | 6.44E-03 |
| PURB | 19291 | purine-rich element binding protein B | regulation of transcription | 2.84E-02 |
| SSH2 | 237860 | slingshot homolog 2 (Drosophila) | actin cytoskeleton organization | 6.46E-03 |
| FNDC3B | 72007 | fibronectin type III domain containing 3B | positive regulation of fat cell differentiation | 1.70E-02 |
| KCNJ8 | 16523 | potassium inwardly-rectifying channel, subfamily J, member 8 | inward rectifier potassium channel activity, kidney development | 6.80E-03 |
| ZFP36L1 | 12192 | zinc finger protein 36, C3H type-like 1 | nuclear-transcribed mRNA catabolic process, vasculogenesis | 2.50E-02 |
| CDS2 | 110911 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 | hosphatidate cytidylyltransferase activity | 5.74E-03 |
| PBXIP1 | 229534 | preB-cell leukemia homeobox interacting protein 1 | transcription corepressor activity, cell differentiation | 4.93E-02 |
| PPP1R9A | 243725 | protein phosphatase 1, regulatory (inhibitor) subunit 9A | regulatory subunit of protein phosphatase I, controls actin cytoskeleton reorganization | 1.60E-02 |
| NID2 | 18074 | nidogen 2 (osteonidogen) | cell-adhesion protein that binds collagens I and IV | 1.08E-03 |
| PKD1 | 18763 | polycystic kidney disease 1 (autosomal dominant) | regulator of calcium permeable cation channels, calcium-independent cell-matrix adhesion | 2.47E-02 |
| SERTAD4 | 214791 | SERTA domain containing 4 | protein binding | 4.78E-02 |
| FBXO46 | 243867 | F-box protein 46 | protein binding | 4.01E-02 |
| SNX18 | 170625 | sorting nexin 18 | cell communication; protein transport | 4.85E-02 |
| PTPRF | 19268 | protein tyrosine phosphatase, receptor type, F | negative regulation of cytokine-mediated signaling pathway, cell adhesion | 2.30E-02 |
| SPCS2 | 66624 | signal peptidase complex subunit 2 homolog (S. cerevisiae) | peptidase activity, signal peptide processing | 2.67E-02 |
| NES | 18008 | nestin | central nervous system development | 5.50E-03 |
| SESN1 | 140742 | sestrin 1 | response to DNA damage stimulus, cell cycle arrest; negative regulation of cell proliferation | 3.94E-02 |
P < 0.05.