Table 4.

Upregulated genes in BdkrB2−/− with Pax2 binding sites

Gene Symbol	Entrez ID	Entrez Name	Molecular Function	Expression in Kidney	Start Position	End Position	Inspecting Sequence ID
Myh8	17885	myosin, heavy chain 8	motor activity, constituent of muscle	trunk mesenchyme	579	591	GXP_92669
Nrxn1	18189	neurexin 1	cell adhesion; axon guidance	trunk mesenchyme	60	72	GXP_185470
Actg2	11468	actin, gamma 2, smooth muscle, enteric	muscle contraction	ureter	240	252	GXP_303411
Myh11	17880	myosin, heavy chain 11, smooth muscle	muscle contraction	vasculature, pelvis, ureter	238	250	GXP_18305
Gprc5d	93746	G protein-coupled receptor, family C, group 5, member D	G protein-coupled receptor activity	N/A	449	461	GXP_2537517
Ahnak	66395	AHNAK nucleoprotein	nervous system development	ureteric tip and trunk, interstitium, vasculature	341	353	GXP_304725
Ccbp2	59289	chemokine binding protein 2	chemokine receptor activity	kidney	402	414	GXP_1805682
Col6a3	12835	collagen, type VI, alpha 3	cell adhesion; muscle organ development	diffused in metanephros	652	664	GXP_1457863
Adamts5	23794	ADAM metallopeptidase with thrombospondin type 1 motif, 5	metalloendopeptidase activity, integrin binding, proteolysis	urogenital sinus, primitive bladder	468	480	GXP_1239277
Sema5a	20356	sema domain, seven thrombospondin repeats	cell adhesion; cell-cell signaling; multicellular organismal development	ureteric tree and tips, vasculature, interstitium, mesenchyme, nephrons	1098	1110	GXP_89931
Col1a2	12843	collagen, type I, alpha 2	extracellular matrix structural constituent	renal vasculature	55	67	GXP_821204
Cav1	12389	caveolin 1, caveolae protein	regulator of the Ras-p42/44 mitogen-activated kinase cascade	trunk mesenchyme	32	44	GXP_150594
Rb1	19645	retinoblastoma 1	Cell cycle progression, apoptosis, proliferation regulator	kidney	546	558	GXP_1793835
Itpr1	16438	inositol 1,4,5-triphosphate receptor, type 1	response to hypoxia, calcium ion transport, ion channel activity	renal vasculature	537	549	GXP_105230
Thbs1	21825	thrombospondin 1	adhesive glycoprotein, cell-to-cell and cell-to-matrix interactions	metanephros, late tubules	410	422	GXP_1459831
Tns1	21961	tensin 1	focal adhesions, cell attaches to the extracellular matrix	proximal and distal tubule, medullary collecting duct	232	244	GXP_2220687
Manba	110173	mannosidase, beta A, lysosomal	hydrolase activity, glycoprotein catabolic process	N/A	256	268	GXP_1799746
Figf	14205	c-fos induced growth factor	PDGF/VEGF family, active in angiogenesis	metanephros	189	201	GXP_1471435
Spnb2	20742	spectrin beta 2	actin binding, calmodulin binding	trunk mesenchyme	551	563	GXP_118730
Zfp26	22688	Mus musculus zinc finger protein 26	DNA binding, metal ion binding, transcription factor, glial development	mesenchyme, ureteric tip and trunk, interstitium, tubules and vasculature	163	175	GXP_826162
Dmd	13405	dystrophin	dystrophin-glycoprotein complex, muscle organ development; skeletal muscle tissue development	metanephros	338	350	GXP_1470974
Icam1	15894	intercellular adhesion molecule 1	receptor activity, integrin binding	N/A	234	246	GXP_445321
Mll5	69188	myeloid/lymphoid or mixed-lineage leukemia 5	Histone methyltransferase, dimethylates 'Lys-4¢ of histone H3, myeloid differentiation	cap mesenchyme, interstitium, pelvic smooth muscle	494	506	GXP_239498
Rbms3	207181	RNA binding motif, single stranded interacting protein 3	DNA replication, gene transcription, cell cycle progression and apoptosis	N/A	267	279	GXP_229583
Nppc	18159	natriuretic peptide precursor C	vasodilating activities, body fluid homeostasis, blood pressure control	N/A	218	230	GXP_288775
Atp7a	11977	ATPase, Cu++ transporting, alpha polypeptide	blood vessel development; blood vessel remodeling	N/A	590	602	GXP_187
Fndc3b	72007	fibronectin type III domain containing 3B	positive regulation of fat cell differentiation	N/A	168	180	GXP_82518
Nes	18008	nestin	neural tube intermediate filamen	drainage component	198	210	GXP_1455614