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. 2014 Jun 27;3(7):644–655. doi: 10.1242/bio.20148334

Fig. 5. The expression of putative immune response genes is modulated in worms exposed to UE-12.

Fig. 5.

(A,C,E) Selected panel of immune response genes analyzed by qRT-PCR in UE-12-treated nematodes and compared to untreated animals (DMSO) following infection by S. aureus. The fold change of all genes tested is relative to the uninfected population (exposed to E. coli OP50). (A) PMK-1 regulated genes. (C) DAF-16 targets. (E) Genes that were reported to be highly regulated in S. aureus infection. (B) Six PMK-1 target genes that were found to be significantly modulated in the presence of UE-12 were tested in the pmk-1 (km25) mutant. (D) Five DAF-16 target genes that were found to be significantly modulated upon exposure to UE-12 were tested in the daf-16 (mu86) mutant. Data are the average of three replicates, each normalized to changes in three primer pairs that were found to not vary with infection. The error bars represent the standard error of the mean. **A significant difference between untreated (DMSO) and UE-12-treated worms (p<0.05).