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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Lancet Respir Med. 2014 May 15;2(7):539–547. doi: 10.1016/S2213-2600(14)70100-6

Figure 1. Mean Relative Change in % predicted FEV1 from Baseline to Week 48 (ITT Population).

Figure 1

The plotted values represent observed data (±SEM). The dotted lines represent the average treatment effect across all post-baseline visits. The p-values were obtained from a mixed-model repeated measures (MMRM) analysis. Covariates were baseline % predicted FEV1, treatment, visit, treatment-by-visit interaction, baseline % predicted FEV1-by-visit interaction, and the stratification factors of baseline inhaled antibiotics (yes vs no), baseline age (<18 vs ≥18 years), and baseline % predicted FEV1 (40 to <65% vs ≥65 to 90%).

Abbreviations: FEV1 = forced expiratory volume in 1 second, ITT = intent-to-treat, MMRM = mixed-model repeated-measures