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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Paediatr Anaesth. 2014 Apr 12;24(7):657–667. doi: 10.1111/pan.12401

Figure 2.

Figure 2

Examples of individual cerebral blood flow (CBF) autoregulation curves. CBF was measured with laser Doppler flowmetry (LDF) in 8 piglets as hypotension was slowly induced. LDF measurements were averaged in 5 mmHg bins of cerebral perfusion pressure (CPP), and the calculated lower limit of autoregulation (LLA) is demarcated with a dotted line. Variation among individual animals is observed in the LDF responses to hypotension. The left column illustrates piglets with relatively horizontal autoregulatory plateaus. The right column illustrates piglets that did not have horizontal LDF curves when CPP exceeded the LLA. Piglets in panels C, F, G, and H display smooth inflections in CBF that are often observed when blood pressure crosses below the lower limit of autoregulation. Reproduced with permission from: Larson AC, Jamrogowicz JL, Kulilkowicz E, Wang B, Yang ZJ, Shaffner DH, Koehler RC, Lee JK. Cerebrovascular autoregulation after rewarming from hypothermia in a neonatal swine model of asphyxic brain injury. J Appl Phyiol 2013; 115(10):1433-42.