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Smurf2 knockdown modulates the PI3K-AKT signaling pathway in a CNKSR2 dependent manner. Smurf2 knockdown diminishes Akt phosphorylation and FoxO3a-dependent cell proliferation. Lysates from control siRNA and Smurf2 siRNA treated MDA-MB-231 cells were probed with the indicated antibodies. β-actin was used as the loading control.
