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. 2014 Sep 4;8:267. doi: 10.3389/fncel.2014.00267

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Copyright © 2014 Lei, Thuault, Launay, Margolskee, Kandel and Siegelbaum.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRPM4 and TRPM5 expression in coronal slices of adult medial PFC (mPFC). Immunofluorescence using antibodies directed against TRPM4, TRPM5 and Neuronal Nuclei (NeuN) performed in coronal slices of mPFC. TRPM4 (magenta) and NeuN (green) double/labeled cells were observed in medial prefrontal cortex (A1–A3) from TRPM4^+/– mice, whereas no TRPM4 immunostaining was observed in sections from TRPM4^−/− (TRPM4-KO) mice (B1–B3). TRPM5^+/– heterozygous mice showed TRPM5 immunoreactivity (C1–C3), whereas no TRPM5 immunostaining was observed in sections from TRPM5^−/− (TRPM5-KO) mice (D1–D3). Staining with TRPM4 and TRPM5 antibody produced predominantly cytosolic labeling and staining of NeuN was primarily localized in the nucleus of the neurons. Scale bars: 50 μm.