Therapeutic dose of radiation impairs longitudinal bone growth regardless of PTH treatment.
(A) Goldner’s trichrome staining of tibial proximal growth plates at day 28 after radiation and PTH treatments. Double-arrow lines indicate the growth plate. NR: non-irradiated left tibia; R: irradiated right tibia.
(B) The average thickness of tibial growth plate was quantified.
(C) The tibial longitudinal growth rate within 28 days after radiation and PTH treatments were calculated based on 3D image registration.
a: p<0.05; b: p<0.01; c: p<0.001 R vs NR. *: p<0.05 vs veh R.