Table II. Fetal HLA specificity of maternal HLA antibodies.

Case		HLA PRA*		Fetal Genotyping (HLA-)						HLA antibodies identified
		Class I	Class II	A	B	C	DQ	DR	DR 51/ 52/ 53	Class I	Class II
1	sPTD	73.9	5.1	33, 68	14, 51	3, 8	2, 7	14, 17	52	A23, A24, A25, A32, B13, B18, B27, B35, B37, B38, B44, B45, B46, B47, B49, B50, B51†, B52, B53, B57, B58, B59, B62, B63, B71, B72, B75, B76, B77, B78, B82, Cw9
2	sPTD	98.5	0.5	2, 68	39, 48	1, 7	4, 9	8, 9	53	A1, A3, A11, A23, A24, A25, A26, A29, A30, A31, A32, A33, A34, A36, A43, A66, A68†, A69, A74, A80, B7, B13, B27, B35, B37, B41, B42, B47, B48†, B51, B52, B55, B60, B61, B62, B67, B72, B73, B75, B78, B81, Cw2, Cw17
3	TD	40.4	1.1	3, 24	38, 39	7, 12	5, 7	1, 16	51	B7, B13, B27, B42, B48, B54, B55, B56, B60, B61, B67, B72, B73, B81, B82	DP14, DR52
4	TD	85.1	60.9	1, 31	40	1, 2	6, 8	4, 13	52, 53	A1, A3, A11, A23, A24, A25, A26, A29, A34, A36, A43, A66, A80, B44, B45, B73, B76, B82, Cw2†, Cw4, Cw5, Cw6, Cw7, Cw15, Cw17, Cw18	DR8, DR11, DR12, DR13†, DR14, DR17, DR18, DR52†
5	sPTD	94.2	1.5	29, 31	39, 44	7, 16	2, 8	4, 7	53	A1, A23, A24, A25, A32, A80, B27, B35, B37, B38, B41, B44†, B45, B46, B47, B49, B50, B51, B52, B53, B57, B58, B59, B60, B61, B62, B63, B71, B72, B75, B76, B77, B82, Cw5	DP11, DQ7, DR13
6	TD	99.9	1.5	3, 11	7, 49	7	2, 6	7, 13	52, 53	A66, B7, B8, B13, B18, B27, B35, B38, B39, B41, B42, B45, B46, B47, B48, B50, B51, B52, B53, B54, B55, B56, B57, B59, B60, B61, B62, B63, B64, B65, B67, B71, B72, B73, B75, B76, B78, B81, B82, Cw2, Cw15, Cw16, Cw17
7	TD	35.1	16.0	2	15, 35	1, 4	8, 9	4, 9	53	B7, B13, B41, B42, B44, B45, B47, B49, B50, B55, B56, B60, B61, B62, B67, B81, B82	DR7, DR18
8	sPTD	90.0	95.0	1, 24	18, 52	5, 12	2, 6	3, 15	51, 52	A1†, A3, A11, A25, A26, A29, A30, A31, A32, A33, A34, A36, A43, A66, A74, A80, B44, B45, B46, B73, B76, Cw1, Cw6, Cw7, Cw8, Cw9, Cw10, Cw12†, Cw14, Cw16, Cw18	DQ4, DQ5, DQ6†, DQ8, DQ9, DR1, DR4, DR7, DR9, DR10, DR15†, DR16 DR51†, DR53, DR103
9	sPTD	94.8	57.7	1, 23	8, 14	6, 8	2, 5	1, 3	52	A2, A23, A24, A25, A32, A68, A69, B13, B27, B35, B37, B38, B41, B44, B45, B46, B47, B49, B50, B51, B52, B53, B55, B56, B57, B58, B59, B60, B61, B62, B63, B71, B72, B75, B77, B76, B77, B78, Cw10	DQ7, DR1†, DR4, DR9, DR10, DR14, DR15, DR51, DR53, DR103
10	sPTD	66.0	17.2	29, 68	39, 44	7, 16	7, 8	4, 14	52, 53	A1, A23, A24, A25, A32, B13, B18, B27, B35, B37, B38, B44†, B45, B47, B49, B50, B51, B52, B53, B57, B58, B59, B62, B63, B71, B72, B75, B76, B77, B78, B82	DR4†, DR13
11	sPTD	84.3	1.0	23, 68	7, 50	5, 7	5, 7	13, 14	52	A32, A66, A74, B7†, B8, B13, B18, B27, B37, B38, B39, B41, B42, B44, B46, B47, B48, B51, B52, B54, B55, B56, B57, B59, B60, B61, B62, B64, B65, B67, B71, B72, B73, B75, B76, B77, B78, B81, B82, Cw1, Cw2, Cw9, Cw10, Cw14, Cw15, Cw17	DP11
12	sPTD	99.6	99.6	2, 31	39, 49	7	5	1	–	A2†, A11, A23, A24, A25, A26, A32, A33, A34, A43, A66, A68, A69, B13, B18, B27, B35, B37, B38, B41, B42, B44, B45, B46, B47, B49†, B50, B51, B52, B53, B54, B55, B56, B57, B58, B59, B60, B61, B62, B63, B64, B65, B71, B67, B71, B72, B73, B75, B76, B77, B78, B82, Cw2, Cw5, Cw6, Cw9, Cw10, Cw15, Cw17, Cw18	DP1, DP2, DP3, DP4, DP5, DP6, DP9, DP10, DP11, DP13, DP14, DP17, DP18, DP19, DP20, DP28, DQ2, DQ4, DQ7, DQ8, DQ9, DR4, DR7, DR8, DR9, DR11, DR12, DR13, DR15, DR16, DR51, DR52, DR103
13	TD	16.5	1.0	2, 24	39, 40	7, 15	6, 8	4, 15	51, 53	B44, B45, B49, B50, B52, B62, B71, B72, B75, B76, B82	DP2, DR8, DR9, DR13, DR18
14	sPTD	66.8	0.5	1, 29	8, 51	7, 16	7, 8	4, 13	52, 53	A23, A24, A25, A32, B13, B18, B27, B35, B37, B38, B44, B45, B47, B49, B51†, B52, B53, B57, B58, B59, B63, B71, B72, B75, B77, B78, Cw1, Cw12, Cw15	DQ2

^*, panel-reactivity (%)

^†, specific against fetal HLA antigens

HLA, human leukocyte antigen; PRA, panel-reactive antibodies; TD, normal term delivery; sPTD, spontaneous preterm delivery