Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Aug 26;6(8):61. doi: 10.1186/s13073-014-0061-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Irizarry et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Hypomethylated blocks occur early in cancer and increase with progression. (A) Across-individual methylation averages for colon normal (green), adenoma (orange), and cancer (purple). The hypomethylated block in cancer is shown in pink. The points represent sample-specific values. Thick lines represent the sample type average, thin lines are each sample. (B) As (A) but the difference from the average normal. (C, D) Summarized average methylation values for blocks (C) and islands (D) in colon normal, adenoma, carcinoma, and metastasis samples. (E, F) Summarized average methylation values for blocks (E) and islands (F) in thyroid normal, benign hyperplastic (adenomatoid nodules), adenoma, minimally invasive carcinoma, capsular invasive carcinoma, vascular invasive carcinoma, and metastatic samples.