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. Author manuscript; available in PMC: 2014 Sep 4.
Published in final edited form as: Ther Deliv. 2013 Apr;4(4):453–462. doi: 10.4155/tde.13.16

Figure 1.

Figure 1

Detection of domain formation by DSC. The formation of a cholesterol domain in lipoplexes is indicated by a heat signal from anhydrous cholesterol as previously described [9]. The DSC thermogram from lipoplexes incorporating 50% long chain PC (24C) demonstrates the distinct thermal signature characteristic of domain formation. In contrast, no heat signal is observed (dashed line) in formulations incorporating 50% short chain PC (14C). Each trace is the average heat signal from 8 individual samples. None of the individual lipid components exhibit transition temperatures from 20–80 °C.