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. Author manuscript; available in PMC: 2014 Sep 4.
Published in final edited form as: Ther Deliv. 2013 Apr;4(4):453–462. doi: 10.4155/tde.13.16

Figure 7.

Figure 7

Serum proteins induce cholesterol domain formation. Lipoplexes composed of 30% DOTAP/20% cholesterol/50% 18C PC were incubated in 50% serum for 30 minutes prior to DSC analysis. A distinct heat signal is observed (solid line) indicating the formation of a cholesterol domain resulting from the adsorption of serum proteins. In contrast, no heat signal is observed when this formulation is incubated in serum-free media (dashed line). Each trace is the average heat signal from 8 individual samples.